| Gene Symbol | PDE4A |
|---|---|
| Entrez Gene | 5141 |
| Alt Symbol | DPDE2, PDE4, PDE46 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphodiesterase 4A, cAMP-specific |
| Other Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4A|phosphodiesterase 4A, cAMP-specific (dunce|phosphodiesterase E2 dunce homolog, Drosophila|phosphodiesterase isozyme 4 |
| Swissprots | Q8IVA7 Q16255 Q5DM53 Q9H3H2 P27815 O76092 Q6PMT2 Q8WUQ3 O75522 Q16691 |
| Accessions | AAA03590 AAC35012 AAC35013 AAC35014 AAC35015 AAG13805 AAG13806 EAW84104 EAW84105 EAW84106 EAW84107 EAW84108 EAW84109 P27815 AF073745 AAD34217 AW138155 AY266362 AAP31234 AY593872 AAT00628 AY618547 AAU82096 BC019864 AAH19864 BC038234 AAH38234 BE266386 BQ009232 DQ892448 ABM83374 DQ895660 ABM86586 L20965 AAA03588 M37744 AAA69697 S75213 AAB33798 U18087 AAC50458 U18088 AAA98540 U68532 AAC63832 U97584 AAC25679 XM_005259933 XP_005259990 XM_011528054 XP_011526356 XM_011528055 XP_011526357 NM_001111307 NP_001104777 NM_001111308 NP_001104778 NM_001111309 NP_001104779 NM_001243121 NP_001230050 NM_006202 NP_006193 |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:17727341}. |
| Subcellular Location | Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic. |
| Tissue Specificity | Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:18095939}. |
| Top Pathways | Morphine addiction, cAMP signaling pathway, Purine metabolism |
PDE4A CRISPR/Cas9 KO Plasmid (h) - sc-403508 from Santa Cruz Biotechnology
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PDE4A HDR Plasmid (h) - sc-403508-HDR from Santa Cruz Biotechnology
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PDE4A Double Nickase Plasmid (h) - sc-403508-NIC from Santa Cruz Biotechnology
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PDE4A Double Nickase Plasmid (h2) - sc-403508-NIC-2 from Santa Cruz Biotechnology
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PDE4A CRISPR Activation Plasmid (h) - sc-403508-ACT from Santa Cruz Biotechnology
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PDE4A CRISPR Activation Plasmid (h2) - sc-403508-ACT-2 from Santa Cruz Biotechnology
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PDE4A Lentiviral Activation Particles (h) - sc-403508-LAC from Santa Cruz Biotechnology
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PDE4A Lentiviral Activation Particles (h2) - sc-403508-LAC-2 from Santa Cruz Biotechnology
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PDE4A siRNA (h) - sc-41596 from Santa Cruz Biotechnology
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PDE4A shRNA Plasmid (h) - sc-41596-SH from Santa Cruz Biotechnology
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PDE4A shRNA (h) Lentiviral Particles - sc-41596-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU096631 from Sigma-Aldrich
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MISSION® esiRNA - EHU141671 from Sigma-Aldrich
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MISSION® esiRNA - EHU088881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1141 from Sigma-Aldrich
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PDE4A siRNA (Human) - CRH3421 from Cohesion Biosciences
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shRNA set against Human PDE4A (NM_006202.2) - SHH372428 from Creative biogene
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shRNA set against Human PDE4A(NM_006202.2) - SHR100122 from Creative biogene
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Human PDE4A siRNA - orb263923 from Biorbyt
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PDE4A shRNA Plasmid (Human) - CHH3421 from Cohesion Biosciences
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PDE4A miRNA 3'UTR clone - MiUTR1H-07705 from Creative biogene
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