PDE4A

Gene Symbol PDE4A
Entrez Gene 5141
Alt Symbol DPDE2, PDE4, PDE46
Species Human
Gene Type protein-coding
Description phosphodiesterase 4A, cAMP-specific
Other Description cAMP-specific 3',5'-cyclic phosphodiesterase 4A|phosphodiesterase 4A, cAMP-specific (dunce|phosphodiesterase E2 dunce homolog, Drosophila|phosphodiesterase isozyme 4
Swissprots Q8IVA7 Q16255 Q5DM53 Q9H3H2 P27815 O76092 Q6PMT2 Q8WUQ3 O75522 Q16691
Accessions AAA03590 AAC35012 AAC35013 AAC35014 AAC35015 AAG13805 AAG13806 EAW84104 EAW84105 EAW84106 EAW84107 EAW84108 EAW84109 P27815 AF073745 AAD34217 AW138155 AY266362 AAP31234 AY593872 AAT00628 AY618547 AAU82096 BC019864 AAH19864 BC038234 AAH38234 BE266386 BQ009232 DQ892448 ABM83374 DQ895660 ABM86586 L20965 AAA03588 M37744 AAA69697 S75213 AAB33798 U18087 AAC50458 U18088 AAA98540 U68532 AAC63832 U97584 AAC25679 XM_005259933 XP_005259990 XM_011528054 XP_011526356 XM_011528055 XP_011526357 NM_001111307 NP_001104777 NM_001111308 NP_001104778 NM_001111309 NP_001104779 NM_001243121 NP_001230050 NM_006202 NP_006193
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:17727341}.
Subcellular Location Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.
Tissue Specificity Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:18095939}.
Top Pathways Morphine addiction, cAMP signaling pathway, Purine metabolism

PDE4A (H-166) - sc-25810 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDE4A (H-166): sc-25810. Western blot analysis of PDE4A expression in non-transfected: sc-117752 (A) and human PDE4A transfected: sc-113958 (B) 293T whole cell lysates.

PDE4A (H-7) - sc-74428 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDE4A (H-7): sc-74428. Western blot analysis of PDE4A expression in SH-SY5Y (A) and Jurkat (B) whole cell lysates.

PDE4A (V-20) - sc-25084 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDE4A1 (N-17) - sc-25080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PDE4A1 (N-17): sc-25080. Western blot analysis of PDE4A1 expression in Jurkat whole cell lysate.

PDE4A2 (S-18) - sc-25081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDE4A5 (L-20) - sc-25082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PDE4 antibody - ab14628 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab 14628 detecting 3 isoforms of PDE4A subclasses (PDE4A1, PDE4A5 and PDE4Ax) and two isoforms of PDE4D (PDE4D1, PDE4D3) in rat brain by Western blot.

Anti-PDE4A (phospho S) antibody - ab14610 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PDE4A (phospho S) antibody (ab14610) at 1 µg/ml + Thyroid (Human) Whole Cell Lysate - adult normal tissue (ab29636) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PDE4A antibody - ab14607 from Abcam

Prices $388.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE4A antibody - ab200383 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PDE4A antibody (ab200383) at 1/300 dilutionLane 1 : HeLa cell lysateLane 2 : A172 cell lysateLysates/proteins at 40 µg per lane.

Anti-PDE4A antibody - ab76853 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PDE4A antibody (ab76853) at 1/500 dilutionLane 1 : PDE4A transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L) HRP-conjugated at 1/5000 dilutiondeveloped using the ECL technique

Anti-PDE4A antibody [6B6] - ab123925 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6B6
ab123925 at 1/100 dilution staining PDE4A in HEK293T cells transfected with either pCMV6-ENTRY PDE4A (Red) or empty vector control plasmid (Blue) by flow cytometry.

Anti-PDE4A4 antibody - ab14609 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE4A5 antibody - ab42094 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PDE4A5 antibody (ab42094) + PDE4A5

Anti-PDE4A5 antibody - ab130550 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PDE4A5 antibody (ab130550) at 1/100 dilution + Mouse cerebellum tissue lysate at 35 µg

Anti-PDE4A5 antibody - ab168737 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-PDE4A5 antibody (ab168737) at 1/500 dilutionLane 1 : PDE4A transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugated secondary antibody at 1/2500 dilution

Anti-PDE4A / PDE4 Antibody (C-Terminus) - LS-C90163 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE4A / PDE4 Antibody - LS-C90162 from LifeSpan Bioscience

Prices $530.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE4A / PDE4 Antibody (C-Terminus) - LS-C82360 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot of PDE4A antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Anti-PDE4A / PDE4 Antibody (aa32-61, AP) - LS-C265881 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4A / PDE4 Antibody (aa32-61, APC) - LS-C265882 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4A / PDE4 Antibody (aa32-61, Biotin) - LS-C265883 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4A / PDE4 Antibody (aa32-61, Azide-free, HRP) - LS-C265885 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4A / PDE4 Antibody (aa32-61, FITC) - LS-C265884 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE4A / PDE4 Antibody (aa32-61, PE) - LS-C265886 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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