PDE4A

Gene Symbol	PDE4A
Entrez Gene	5141
Alt Symbol	DPDE2, PDE4, PDE46
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 4A, cAMP-specific
Other Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A|phosphodiesterase 4A, cAMP-specific (dunce|phosphodiesterase E2 dunce homolog, Drosophila|phosphodiesterase isozyme 4
Swissprots	Q8IVA7 Q16255 Q5DM53 Q9H3H2 P27815 O76092 Q6PMT2 Q8WUQ3 O75522 Q16691
Accessions	AAA03590 AAC35012 AAC35013 AAC35014 AAC35015 AAG13805 AAG13806 EAW84104 EAW84105 EAW84106 EAW84107 EAW84108 EAW84109 P27815 AF073745 AAD34217 AW138155 AY266362 AAP31234 AY593872 AAT00628 AY618547 AAU82096 BC019864 AAH19864 BC038234 AAH38234 BE266386 BQ009232 DQ892448 ABM83374 DQ895660 ABM86586 L20965 AAA03588 M37744 AAA69697 S75213 AAB33798 U18087 AAC50458 U18088 AAA98540 U68532 AAC63832 U97584 AAC25679 XM_005259933 XP_005259990 XM_011528054 XP_011526356 XM_011528055 XP_011526357 NM_001111307 NP_001104777 NM_001111308 NP_001104778 NM_001111309 NP_001104779 NM_001243121 NP_001230050 NM_006202 NP_006193
Function	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269|PubMed:11566027, ECO:0000269|PubMed:17727341}.
Subcellular Location	Isoform 7: Cytoplasm. Membrane. Note=Predominantly cytoplasmic.
Tissue Specificity	Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level). {ECO:0000269|PubMed:11306681, ECO:0000269|PubMed:15738310, ECO:0000269|PubMed:18095939}.
Top Pathways	Morphine addiction, cAMP signaling pathway, Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDE4A full length protein - ab198423 from Abcam Category Protein Prices $1,250.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PDE4A full length protein - ab198466 from Abcam Category Protein Prices $1,250.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PDE4A protein fragment - ab125603 from Abcam Category Protein Prices $302.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human PDE4A full length protein - ab117037 from Abcam Category Protein Source Wheat germ Species Human

PDE4A peptide - ab169988 from Abcam Category Peptide

PDE4A / PDE4 Antibody Blocking Peptide - LS-E4801 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Phosphodiesterase 4A/PDE4A Recombinant Protein - H00005141-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDE4A-Antibody-N-term-Blocking-Peptide - BP17181a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Phosphodiesterase 4A/PDE4A, CF - 7767-PE-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Pro331-Met723, with an N-terminal Met and a C-terminal 6-His tag

PDE4A - H00005141-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PDE4A - H00005141-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PDE4A control peptide - AP10213CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

PDE4A control peptide - AP10214CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

PDE4A control peptide - AP10216CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

PDE4A1 control peptide - AP10215CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

PDE4A5 control peptide - AP10217CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

PDE4A10 control peptide - AP10219CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

PDE4A11 control peptide - AP10220CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

Phosphodiesterase 4 control peptide - AP10212CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

PDE4A fusion protein - ag3825 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PDE4A fusion protein - Ag8018 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PDE4A10 Active Human Recombinant Protein - GWB-PS90FE from Genway Biotech Category Protein Prices $600.00 Sizes 10 µg Species Human

PDE4A4B Active Human Recombinant Protein - GWB-PSF5A3 from Genway Biotech Category Protein Prices $600.00 Sizes 10 µg Species Human

PDE4A1A, Active Human Recombinant Protein - GWB-4DB22F from Genway Biotech Category Protein Prices $600.00 Sizes 10 µg Species Human

Recombinant Human PDE4A, GST-tagged, Active - PDE4A-475H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Search more