DNPH1

Gene Symbol	DNPH1
Entrez Gene	10591
Alt Symbol	C6orf108, RCL, dJ330M21.3
Species	Human
Gene Type	protein-coding
Description	2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Other Description	c-Myc-responsive protein RCL\|c-Myc-responsive protein Rcl\|deoxyribonucleoside 5'-monophosphate N-glycosidase\|putative c-Myc-responsive
Swissprots	B2LUJ9 O43598
Accessions	EAX04165 EAX04166 O43598 AF040105 AAB96766 BC011683 AAH11683 BM747628 BQ052226 EU585603 ACB87500 NM_006443 NP_006434 NM_199184 NP_954653
Function	Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. {ECO:0000255\|HAMAP-Rule:MF_03036, ECO:0000269\|PubMed:24260472, ECO:0000269\|PubMed:25108359}.
Subcellular Location	Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_03036, ECO:0000269\|PubMed:18726892}. Nucleus {ECO:0000255\|HAMAP- Rule:MF_03036}.
Tissue Specificity	Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. {ECO:0000269\|PubMed:18726892}.

RCL (A-7) - sc-365683 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

RCL (A-7): sc-365683. Western blot analysis of RCL expression in Hep G2 whole cell lysate.

RCL (C-8) - sc-365682 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

RCL (C-8): sc-365682. Western blot analysis of RCL expression in K-562 whole cell lysate.

RCL (E-15) - sc-169122 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

RCL (FL-174) - sc-135385 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

RCL (FL-174): sc-135385. Western blot analysis of RCL expression in Hep G2 whole cell lysate.

RCL (G-13) - sc-169123 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-RCL antibody - ab201290 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-RCL antibody (ab201290) at 0.1 µg/mlLane 1 : HeLa whole cell lysateLane 2 : 293T whole cell lysateLane 3 : Jurkat whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-RCL antibody - ab107324 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RCL antibody (ab107324) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-RCL antibody - ab138033 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RCL antibody (ab138033) at 1/500 dilution + 293 cell lysate at 30 µg

Anti-RCL antibody [EPR8685] - ab150413 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8685

All lanes : Anti-RCL antibody [EPR8685] (ab150413) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLane 3 : HepG2 cell lysateLane 4 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-RCL antibody [EPR8686] - ab131252 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8686

All lanes : Anti-RCL antibody [EPR8686] (ab131252) at 1/10000 dilutionLane 1 : K562 cell lysateLane 2 : HepG2 cell lysateLane 3 : HeLa cell lysateLane 4 : Jurkat cell lysateLane 5 : MCF7 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti Rabbit IgG at 1/2000 dilution

Anti-RCL antibody - C-terminal - ab166737 from Abcam

Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-RCL antibody - C-terminal (ab166737) at 1/1000 dilutionLane 1 : HeLa cell extractLane 2 : Jurkat cell extract

Anti-C6orf108 Antibody (aa20-48, APC) - LS-C267995 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-C6orf108 Antibody (aa20-48, AP) - LS-C267996 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-C6orf108 Antibody (aa20-48, Biotin) - LS-C267998 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-C6orf108 Antibody (aa20-48, FITC) - LS-C267999 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-C6orf108 Antibody (aa20-48, Azide-free, HRP) - LS-C268000 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-C6orf108 Antibody (aa27-56) - LS-C324590 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-C6orf108 Antibody (aa20-48, PE) - LS-C268001 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-C6orf108 Antibody (aa42-91) - LS-C200575 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of the lysates from 293 cells using RCL antibody.

Anti-C6orf108 Antibody (Ile42) - LS-C177813 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of RCL (I42) pAb in extracts from Jurkat cells.

Anti-C6orf108 Antibody (aa1-50) - LS-C119864 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from Jurkat/K562 cells, using RCL Antibody. The lane on the right is treated with the synthesized peptide.

Anti-C6orf108 Antibody (Internal, clone EPR8686) - LS-C154550 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR8686

IHC of paraffin-embedded human breast carcinoma tissue using anti-C6orf108 antibody.

Anti-C6orf108 Antibody (aa20-48) - LS-C162517 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

RCL Antibody western blot of CEM cell line lysates (35 ug/lane). The RCL antibody detected the RCL protein (arrow).

c-Myc-responsive protein Rcl Antibody - NBP1-85180 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: c-Myc-responsive protein Rcl Antibody [NBP1-85180] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

c-Myc-responsive protein Rcl Antibody - NBP1-85181 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: c-Myc-responsive protein Rcl Antibody [NBP1-85181] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

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