Gene Symbol | DNPH1 |
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Entrez Gene | 10591 |
Alt Symbol | C6orf108, RCL, dJ330M21.3 |
Species | Human |
Gene Type | protein-coding |
Description | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
Other Description | c-Myc-responsive protein RCL|c-Myc-responsive protein Rcl|deoxyribonucleoside 5'-monophosphate N-glycosidase|putative c-Myc-responsive |
Swissprots | B2LUJ9 O43598 |
Accessions | EAX04165 EAX04166 O43598 AF040105 AAB96766 BC011683 AAH11683 BM747628 BQ052226 EU585603 ACB87500 NM_006443 NP_006434 NM_199184 NP_954653 |
Function | Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. {ECO:0000255|HAMAP-Rule:MF_03036, ECO:0000269|PubMed:24260472, ECO:0000269|PubMed:25108359}. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03036, ECO:0000269|PubMed:18726892}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03036}. |
Tissue Specificity | Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. {ECO:0000269|PubMed:18726892}. |
RCL CRISPR/Cas9 KO Plasmid (h) - sc-411487 from Santa Cruz Biotechnology
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RCL HDR Plasmid (h) - sc-411487-HDR from Santa Cruz Biotechnology
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RCL Double Nickase Plasmid (h) - sc-411487-NIC from Santa Cruz Biotechnology
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RCL Double Nickase Plasmid (h2) - sc-411487-NIC-2 from Santa Cruz Biotechnology
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RCL CRISPR Activation Plasmid (h) - sc-411487-ACT from Santa Cruz Biotechnology
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RCL CRISPR Activation Plasmid (h2) - sc-411487-ACT-2 from Santa Cruz Biotechnology
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RCL Lentiviral Activation Particles (h) - sc-411487-LAC from Santa Cruz Biotechnology
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RCL Lentiviral Activation Particles (h2) - sc-411487-LAC-2 from Santa Cruz Biotechnology
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RCL siRNA (h) - sc-95242 from Santa Cruz Biotechnology
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RCL shRNA Plasmid (h) - sc-95242-SH from Santa Cruz Biotechnology
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RCL shRNA (h) Lentiviral Particles - sc-95242-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5011 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02829 from Sigma-Aldrich
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DNPH1 siRNA (Human) - CRH7209 from Cohesion Biosciences
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DNPH1 - MBS8203098 from MyBioSource
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shRNA set against Human C6orf108 (NM_006443.2) - SHH252165 from Creative biogene
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shRNA set against Human C6orf108(NM_199184.1) - SHG126739 from Creative biogene
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shRNA set against Human C6orf108(NM_006443.2) - SHG126757 from Creative biogene
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Human DNPH1 siRNA - orb267711 from Biorbyt
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DNPH1 shRNA Plasmid (Human) - CHH7209 from Cohesion Biosciences
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C6ORF108 miRNA 3'UTR clone - MiUTR1H-01434 from Creative biogene
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C6ORF108 miRNA 3'UTR clone - MiUTR1H-01435 from Creative biogene
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