| Gene Symbol |
DNPH1
|
| Entrez Gene |
10591
|
| Alt Symbol |
C6orf108, RCL, dJ330M21.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
|
| Other Description |
c-Myc-responsive protein RCL|c-Myc-responsive protein Rcl|deoxyribonucleoside 5'-monophosphate N-glycosidase|putative c-Myc-responsive
|
| Swissprots |
B2LUJ9 O43598
|
| Accessions |
EAX04165 EAX04166 O43598 AF040105 AAB96766 BC011683 AAH11683 BM747628 BQ052226 EU585603 ACB87500 NM_006443 NP_006434 NM_199184 NP_954653
|
| Function |
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases. {ECO:0000255|HAMAP-Rule:MF_03036, ECO:0000269|PubMed:24260472, ECO:0000269|PubMed:25108359}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03036, ECO:0000269|PubMed:18726892}. Nucleus {ECO:0000255|HAMAP- Rule:MF_03036}.
|
| Tissue Specificity |
Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers. {ECO:0000269|PubMed:18726892}.
|
![Western Blot: c-Myc-responsive protein Rcl Overexpression Lysate (Adult Normal) [NBL1-08506] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for c-Myc-responsive protein Rcl.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11795_c-Myc-responsive%2520protein%2520Rcl%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-08506-img0002.jpg)