Gene Symbol | LRP2 |
---|---|
Entrez Gene | 4036 |
Alt Symbol | DBS, GP330 |
Species | Human |
Gene Type | protein-coding |
Description | low density lipoprotein receptor-related protein 2 |
Other Description | Heymann nephritis antigen homolog|LRP-2|calcium sensor protein|glycoprotein 330|low-density lipoprotein receptor-related protein 2|megalin |
Swissprots | O00711 Q16215 P98164 |
Accessions | AAC17129 AAX88965 AAY24266 CCQ43266 EAX11280 P98164 AK295005 BAG58066 AK302843 BAG64033 AY265357 AAP88585 AY265358 AAP88586 CD673312 DA200673 DA339827 DA401915 S73145 AAB30825 U04441 AAB02882 U33837 AAB41649 XM_011511183 XP_011509485 XM_011511184 XP_011509486 XM_011511185 XP_011509487 NM_004525 NP_004516 |
Function | Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. {ECO:0000250}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. Membrane, coated pit. |
Tissue Specificity | Absorptive epithelia, including renal proximal tubules. |
Top Pathways | Hedgehog signaling pathway, Thyroid hormone synthesis |
megalin CRISPR/Cas9 KO Plasmid (h) - sc-401094 from Santa Cruz Biotechnology
|
||||||||
megalin HDR Plasmid (h) - sc-401094-HDR from Santa Cruz Biotechnology
|
||||||||
megalin Double Nickase Plasmid (h) - sc-401094-NIC from Santa Cruz Biotechnology
|
||||||||
megalin Double Nickase Plasmid (h2) - sc-401094-NIC-2 from Santa Cruz Biotechnology
|
||||||||
megalin CRISPR Activation Plasmid (h) - sc-401094-ACT from Santa Cruz Biotechnology
|
||||||||
megalin CRISPR Activation Plasmid (h2) - sc-401094-ACT-2 from Santa Cruz Biotechnology
|
||||||||
megalin Lentiviral Activation Particles (h) - sc-401094-LAC from Santa Cruz Biotechnology
|
||||||||
megalin Lentiviral Activation Particles (h2) - sc-401094-LAC-2 from Santa Cruz Biotechnology
|
||||||||
megalin siRNA (h) - sc-40103 from Santa Cruz Biotechnology
|
||||||||
megalin shRNA Plasmid (h) - sc-40103-SH from Santa Cruz Biotechnology
|
||||||||
megalin shRNA (h) Lentiviral Particles - sc-40103-V from Santa Cruz Biotechnology
|
||||||||
LRP2 RNAi - H00004036-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU043401 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN12692 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12692 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR09788 from Sigma-Aldrich
|
||||||||
LRP2 siRNA (Human) - CRH2728 from Cohesion Biosciences
|
||||||||
shRNA set against Human LRP2 (NM_004525.2) - SHH334007 from Creative biogene
|
||||||||
shRNA set against Human LRP2(NM_004525.2) - SHH161165 from Creative biogene
|
||||||||
Human LRP2 siRNA - orb263230 from Biorbyt
|
||||||||
LRP2 shRNA Plasmid (Human) - CHH2728 from Cohesion Biosciences
|
||||||||
LRP2 miRNA 3'UTR clone - MiUTR1H-05899 from Creative biogene
|