| Gene Symbol | IL27RA |
|---|---|
| Entrez Gene | 9466 |
| Alt Symbol | CRL1, IL-27RA, IL27R, TCCR, WSX1, zcytor1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 27 receptor, alpha |
| Other Description | IL-27 receptor subunit alpha|IL-27R subunit alpha|IL-27R-alpha|T-cell cytokine receptor type 1|class I cytokine receptor|cytokine receptor WSX-1|cytokine receptor-like 1|interleukin-27 receptor subunit alpha|type I T-cell cytokine receptor |
| Swissprots | A0N0L1 Q6UWB1 O60624 |
| Accessions | ABK41902 CAV32862 CBX32720 EAW84389 EAW84390 Q6UWB1 AF053004 AAC39755 AF106912 AAG26090 AF265242 AAG27297 AI983115 AW298502 AY358876 AAQ89235 BC028003 AAH28003 DQ891051 ABM81977 DQ894230 ABM85156 NM_004843 NP_004834 |
| Function | Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. {ECO:0000269|PubMed:14764690}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B- cells and monocytes. {ECO:0000269|PubMed:11057672, ECO:0000269|PubMed:9600072}. |