| Gene Symbol |
Pea15a
|
| Entrez Gene |
18611
|
| Alt Symbol |
Mat1, PEA-15, Pea15, Pkcs15
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
phosphoprotein enriched in astrocytes 15A
|
| Other Description |
15 kDa phosphoprotein enriched in astrocytes|astrocytic phosphoprotein PEA-15|mammary transforming gene 1|phosphoprotein enriched in astrocytes 15
|
| Swissprots |
Q3U5N7 Q62048
|
| Accessions |
CAA60387 EDL39031 EDL39032 EDL39033 Q62048 AK077421 AK089070 BAC40734 AK153141 BAE31752 AK153493 BAE32041 AK161635 BAE36504 AK161977 BAE36662 AK179140 BC038282 AAH38282 BC092079 BY122161 G49234 L31958 AAC37665 XM_006496702 XP_006496765 NM_011063 NP_035193
|
| Function |
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10926929}. Note=Associated with microtubules.
|
| Tissue Specificity |
Predominantly expressed in the brain. Low levels in some peripheral organs.
|