Gene Symbol | Pea15a |
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Entrez Gene | 18611 |
Alt Symbol | Mat1, PEA-15, Pea15, Pkcs15 |
Species | Mouse |
Gene Type | protein-coding |
Description | phosphoprotein enriched in astrocytes 15A |
Other Description | 15 kDa phosphoprotein enriched in astrocytes|astrocytic phosphoprotein PEA-15|mammary transforming gene 1|phosphoprotein enriched in astrocytes 15 |
Swissprots | Q3U5N7 Q62048 |
Accessions | CAA60387 EDL39031 EDL39032 EDL39033 Q62048 AK077421 AK089070 BAC40734 AK153141 BAE31752 AK153493 BAE32041 AK161635 BAE36504 AK161977 BAE36662 AK179140 BC038282 AAH38282 BC092079 BY122161 G49234 L31958 AAC37665 XM_006496702 XP_006496765 NM_011063 NP_035193 |
Function | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10926929}. Note=Associated with microtubules. |
Tissue Specificity | Predominantly expressed in the brain. Low levels in some peripheral organs. |
PEA-15 CRISPR/Cas9 KO Plasmid (m) - sc-422184 from Santa Cruz Biotechnology
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PEA-15 HDR Plasmid (m) - sc-422184-HDR from Santa Cruz Biotechnology
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PEA-15 Double Nickase Plasmid (m) - sc-422184-NIC from Santa Cruz Biotechnology
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PEA-15 Double Nickase Plasmid (m2) - sc-422184-NIC-2 from Santa Cruz Biotechnology
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PEA-15 CRISPR Activation Plasmid (m) - sc-422184-ACT from Santa Cruz Biotechnology
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PEA-15 CRISPR Activation Plasmid (m2) - sc-422184-ACT-2 from Santa Cruz Biotechnology
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PEA-15 Lentiviral Activation Particles (m) - sc-422184-LAC from Santa Cruz Biotechnology
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PEA-15 Lentiviral Activation Particles (m2) - sc-422184-LAC-2 from Santa Cruz Biotechnology
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PEA-15 siRNA (m) - sc-37486 from Santa Cruz Biotechnology
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PEA-15 shRNA Plasmid (m) - sc-37486-SH from Santa Cruz Biotechnology
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PEA-15 shRNA (m) Lentiviral Particles - sc-37486-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU165181 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38529 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38529 from Sigma-Aldrich
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PEA15 siRNA (Mouse) - CRM3017 from Cohesion Biosciences
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shRNA set against Mouse Pea15a (NM_011063.2) - SHH373320 from Creative biogene
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Mouse PEA15 siRNA - orb282493 from Biorbyt
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PEA15 shRNA Plasmid (Mouse) - CHM3017 from Cohesion Biosciences
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PEA15A miRNA 3'UTR clone - MiUTR1M-09092 from Creative biogene
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