| Gene Symbol |
ERP44
|
| Entrez Gene |
23071
|
| Alt Symbol |
PDIA10, TXNDC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endoplasmic reticulum protein 44
|
| Other Description |
ER protein 44|endoplasmic reticulum resident protein 44|endoplasmic reticulum resident protein 44 kDa|protein disulfide isomerase family A, member 10|thioredoxin domain containing 4 (endoplasmic reticulum)|thioredoxin domain-containing protein 4
|
| Swissprots |
Q9BS26 Q5VWZ7 Q6UW14 Q8WX67 Q4VXC1 O60319
|
| Accessions |
CAF86876 EAW58922 EAW58923 Q9BS26 AB011145 BAA25499 AJ344330 CAC87611 AK075024 BAG52054 AY359048 AAQ89407 BC005374 AAH05374 BQ881761 BX648519 NM_015051 NP_055866
|
| Function |
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240}.
|
| Subcellular Location |
Endoplasmic reticulum lumen.
|
![Western Blot: ERP44 Overexpression Lysate (Adult Normal) [NBL1-17471] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ERP44.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4555_ERP44%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17471-img0002.jpg)