Gene Symbol | ERP44 |
---|---|
Entrez Gene | 23071 |
Alt Symbol | PDIA10, TXNDC4 |
Species | Human |
Gene Type | protein-coding |
Description | endoplasmic reticulum protein 44 |
Other Description | ER protein 44|endoplasmic reticulum resident protein 44|endoplasmic reticulum resident protein 44 kDa|protein disulfide isomerase family A, member 10|thioredoxin domain containing 4 (endoplasmic reticulum)|thioredoxin domain-containing protein 4 |
Swissprots | Q9BS26 Q5VWZ7 Q6UW14 Q8WX67 Q4VXC1 O60319 |
Accessions | CAF86876 EAW58922 EAW58923 Q9BS26 AB011145 BAA25499 AJ344330 CAC87611 AK075024 BAG52054 AY359048 AAQ89407 BC005374 AAH05374 BQ881761 BX648519 NM_015051 NP_055866 |
Function | Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240}. |
Subcellular Location | Endoplasmic reticulum lumen. |