HOMER2

Gene Symbol HOMER2
Entrez Gene 9455
Alt Symbol ACPD, CPD, HOMER-2, VESL-2
Species Human
Gene Type protein-coding
Description homer scaffolding protein 2
Other Description cupidin|homer homolog 2|homer homolog 3|homer protein homolog 2|homer, neuronal immediate early gene, 2
Swissprots Q9NSB6 Q9UNT7 Q9NSB7 O95269 O95349 Q9NSB8
Accessions EAW62435 EAW62436 Q9NSB8 AF081530 AAD13748 AF093263 AAC71027 AF093264 AAC71028 AK292772 BAF85461 AY062316 AAL65744 BC012109 AAH12109 BC044934 BI666912 CB321822 CR936744 DQ892324 ABM83250 DQ895526 ABM86452 Y19025 CAB75537 Y19026 CAB75538 Y19027 CAB75539 Y19028 CAB75540 XM_005272448 XP_005272505 XM_005272449 XP_005272506 XM_006720775 XP_006720838 XM_006720776 XP_006720839 XM_011522231 XP_011520533 XM_011522232 XP_011520534 XM_011522233 XP_011520535 XM_011522234 XP_011520536 NM_004839 NP_004830 NM_199330 NP_955362 NM_199331 NM_199332
Function Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
Subcellular Location Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
Top Pathways Glutamatergic synapse

Homer-2a/b (C-16) - sc-8924 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Homer-2a/b (C-16): sc-8924. Western blot analysis of Homer-2a/b expression in non-transfected: sc-117752 (A) and human Homer-2a/b transfected: sc-176532 (B) 293T whole cell lysates.

Anti-HOMER2 antibody - ab108542 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HOMER2 antibody (ab108542) at 1/500 dilution + Human fetal liver lysate

Anti-HOMER2 antibody - ab103496 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HOMER2 antibody (ab103496) at 1/500 dilution + Mouse brain lysate at 50 µg

Anti-HOMER2 antibody - ab68214 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-HOMER2 antibody (ab68214) at 1/500 dilution + rat brain tissue lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-HOMER2 / Homer 2 Antibody - LS-C178429 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HOMER2 / Homer 2 Antibody - LS-C308280 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HOMER2 / Homer 2 Antibody - LS-C310641 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HOMER2 / Homer 2 Antibody - LS-C310638 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HOMER2 / Homer 2 Antibody (clone 4D4) - LS-C339913 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HOMER2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HOMER2.

Anti-HOMER2 / Homer 2 Antibody (clone 4G6) - LS-C339914 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HOMER2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HOMER2.

Anti-HOMER2 / Homer 2 Antibody (clone 2D5) - LS-C339919 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D5
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HOMER2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HOMER2.

Anti-HOMER2 / Homer 2 Antibody (clone 2E10) - LS-C339920 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2E10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HOMER2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HOMER2.

Anti-HOMER2 / Homer 2 Antibody (clone 2B3) - LS-C339921 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HOMER2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HOMER2.

Anti-HOMER2 / Homer 2 Antibody (clone 1D1) - LS-C340653 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HOMER2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HOMER2.

Anti-HOMER2 / Homer 2 Antibody (aa153-202) - LS-C170359 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

HOMER2 Antibody - NBP1-85487 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: HOMER2 Antibody [NBP1-85487] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue

HOMER2 Antibody - NB100-98712 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HOMER2 Antibody - H00009455-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: HOMER2 Antibody [H00009455-D01P] - MER2 MaxPab rabbit polyclonal antibody. Western Blot analysis of HOMER2 expression in mouse brain.

HOMER2 Antibody - H00009455-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: HOMER2 Antibody [H00009455-B01P] - Analysis of HOMER2 expression in rat brain.

HOMER2 Antibody - H00009455-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

HOMER2 Antibody - NBP1-31861 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

HOMER2 Polyclonal Antibody - bs-4632R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HOMER2 antibody produced in rabbit - SAB1411660 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HOMER2: <B>Cat. No. SAB1411660</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~40.6 kDa using A-431 lysate.

Anti-HOMER2 (143-155) antibody produced in rabbit - SAB1100634 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-HOMER2 (143-155) : <B>Cat. No. SAB1100634</B>: Immunofluorescence of HUVEC cells using HOMER2 (143-155) , Cat. No. SAB1100634 (red) at a 1:200 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-HOMER2 antibody produced in mouse - SAB1400346 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-HOMER2, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400346</B>: Antibody concentration: 1.0 ~ 5.0 μg/mL. Specific band of ~40.6 kDa using rat brain lysate.
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