| Gene Symbol |
HOMER2
|
| Entrez Gene |
9455
|
| Alt Symbol |
ACPD, CPD, HOMER-2, VESL-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
homer scaffolding protein 2
|
| Other Description |
cupidin|homer homolog 2|homer homolog 3|homer protein homolog 2|homer, neuronal immediate early gene, 2
|
| Swissprots |
Q9NSB6 Q9UNT7 Q9NSB7 O95269 O95349 Q9NSB8
|
| Accessions |
EAW62435 EAW62436 Q9NSB8 AF081530 AAD13748 AF093263 AAC71027 AF093264 AAC71028 AK292772 BAF85461 AY062316 AAL65744 BC012109 AAH12109 BC044934 BI666912 CB321822 CR936744 DQ892324 ABM83250 DQ895526 ABM86452 Y19025 CAB75537 Y19026 CAB75538 Y19027 CAB75539 Y19028 CAB75540 XM_005272448 XP_005272505 XM_005272449 XP_005272506 XM_006720775 XP_006720838 XM_006720776 XP_006720839 XM_011522231 XP_011520533 XM_011522232 XP_011520534 XM_011522233 XP_011520535 XM_011522234 XP_011520536 NM_004839 NP_004830 NM_199330 NP_955362 NM_199331 NM_199332
|
| Function |
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
|
| Subcellular Location |
Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
|
| Top Pathways |
Glutamatergic synapse
|