| Gene Symbol |
RASA4
|
| Entrez Gene |
10156
|
| Alt Symbol |
CAPRI, GAPL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAS p21 protein activator 4
|
| Other Description |
Ca2+-promoted Ras inactivator|calcium-promoted Ras inactivator|ras GTPase-activating protein 4|rasGAP-activating-like protein 2
|
| Swissprots |
Q96QU0 Q86UW3 Q14CQ4 O60286 O43374
|
| Accessions |
AAB97935 AAP22345 EAW61133 O43374 AB011110 BAA25464 AK026441 AK093486 AK302370 BAG63692 AK308653 AK310176 AK315928 BAH14299 BC110873 AAI10874 BC113663 AAI13664 BC143584 AAI43585 BC143585 BG289308 BQ890546 DA028746 DA841834 DB114101 HQ258652 ADR83403 XM_005250104 XP_005250161 XM_011515723 XP_011514025 XR_428164 XR_927325 NM_001079877 NP_001073346 NM_006989 NP_008920
|
| Function |
Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:11448776}. Cell membrane {ECO:0000269|PubMed:11448776}; Peripheral membrane protein {ECO:0000269|PubMed:11448776}. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11448776}.
|