Gene Symbol | RASA4 |
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Entrez Gene | 10156 |
Alt Symbol | CAPRI, GAPL |
Species | Human |
Gene Type | protein-coding |
Description | RAS p21 protein activator 4 |
Other Description | Ca2+-promoted Ras inactivator|calcium-promoted Ras inactivator|ras GTPase-activating protein 4|rasGAP-activating-like protein 2 |
Swissprots | Q96QU0 Q86UW3 Q14CQ4 O60286 O43374 |
Accessions | AAB97935 AAP22345 EAW61133 O43374 AB011110 BAA25464 AK026441 AK093486 AK302370 BAG63692 AK308653 AK310176 AK315928 BAH14299 BC110873 AAI10874 BC113663 AAI13664 BC143584 AAI43585 BC143585 BG289308 BQ890546 DA028746 DA841834 DB114101 HQ258652 ADR83403 XM_005250104 XP_005250161 XM_011515723 XP_011514025 XR_428164 XR_927325 NM_001079877 NP_001073346 NM_006989 NP_008920 |
Function | Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. {ECO:0000269|PubMed:11448776}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:11448776}. Cell membrane {ECO:0000269|PubMed:11448776}; Peripheral membrane protein {ECO:0000269|PubMed:11448776}. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11448776}. |
RASA4 CRISPR/Cas9 KO Plasmid (h) - sc-409219 from Santa Cruz Biotechnology
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RASA4 HDR Plasmid (h) - sc-409219-HDR from Santa Cruz Biotechnology
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RASA4 Double Nickase Plasmid (h) - sc-409219-NIC from Santa Cruz Biotechnology
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RASA4 Double Nickase Plasmid (h2) - sc-409219-NIC-2 from Santa Cruz Biotechnology
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RASA4 CRISPR Activation Plasmid (h) - sc-409219-ACT from Santa Cruz Biotechnology
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RASA4 CRISPR Activation Plasmid (h2) - sc-409219-ACT-2 from Santa Cruz Biotechnology
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RASA4 Lentiviral Activation Particles (h) - sc-409219-LAC from Santa Cruz Biotechnology
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RASA4 Lentiviral Activation Particles (h2) - sc-409219-LAC-2 from Santa Cruz Biotechnology
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RASA4 siRNA (h) - sc-89880 from Santa Cruz Biotechnology
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RASA4 shRNA Plasmid (h) - sc-89880-SH from Santa Cruz Biotechnology
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RASA4 shRNA (h) Lentiviral Particles - sc-89880-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU117951 from Sigma-Aldrich
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MISSION® esiRNA - EHU117981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17971 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13881 from Sigma-Aldrich
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RASA4 siRNA (Human) - CRH6855 from Cohesion Biosciences
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RASA4 - MBS8230420 from MyBioSource
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shRNA set against Human Rasa4 (NM_006989.5) - SHH389884 from Creative biogene
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Human RASA4 siRNA - orb267357 from Biorbyt
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RASA4 shRNA Plasmid (Human) - CHH6855 from Cohesion Biosciences
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RASA4 miRNA 3'UTR clone - MiUTR4H-TG07334 from Creative biogene
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