Gene Symbol |
PIN4
|
Entrez Gene |
5303
|
Alt Symbol |
EPVH, PAR14, PAR17
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
peptidylprolyl cis/trans isomerase, NIMA-interacting 4
|
Other Description |
PPIase PIN4|eukaryotic parvulin homolog|hEPVH|hPar14|hPar17|parvulin|parvulin-14|parvulin-17|peptidyl-prolyl cis-trans isomerase NIMA-interacting 4|peptidyl-prolyl cis-trans isomerase Pin4|peptidyl-prolyl cis/trans isomerase EPVH|peptidylprolyl cis/trans isomerase NIMA-interacting, 4|protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)|rotamase PIN4
|
Swissprots |
A8E0G6 Q9Y237 Q52M21 F5H1P5 Q3MHV0 Q0D2H3 Q5HYW6 B3KXM0 Q6IRW4
|
Accessions |
CAM12362 CAM12363 CAM12364 EAW71812 Q9Y237 AB009690 BAA82320 AF143096 AAD27893 AK127605 BAG54532 AU098526 AV709926 BC005234 AAH05234 BC070288 AAH70288 BC093700 AAH93700 BC104653 AAI04654 BC111394 AAI11395 BC112281 AAI12282 BE504461 BU952002 HQ258728 ADR83479 NM_001170747 NP_001164218 NM_006223 NP_006214 NR_033187
|
Function |
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. {ECO:0000269|PubMed:19369196}.
|
Subcellular Location |
Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.
|
Tissue Specificity |
Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed. {ECO:0000269|PubMed:10100858, ECO:0000269|PubMed:10364457, ECO:0000269|PubMed:16522211}.
|