Gene Symbol | PIN4 |
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Entrez Gene | 5303 |
Alt Symbol | EPVH, PAR14, PAR17 |
Species | Human |
Gene Type | protein-coding |
Description | peptidylprolyl cis/trans isomerase, NIMA-interacting 4 |
Other Description | PPIase PIN4|eukaryotic parvulin homolog|hEPVH|hPar14|hPar17|parvulin|parvulin-14|parvulin-17|peptidyl-prolyl cis-trans isomerase NIMA-interacting 4|peptidyl-prolyl cis-trans isomerase Pin4|peptidyl-prolyl cis/trans isomerase EPVH|peptidylprolyl cis/trans isomerase NIMA-interacting, 4|protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)|rotamase PIN4 |
Swissprots | A8E0G6 Q9Y237 Q52M21 F5H1P5 Q3MHV0 Q0D2H3 Q5HYW6 B3KXM0 Q6IRW4 |
Accessions | CAM12362 CAM12363 CAM12364 EAW71812 Q9Y237 AB009690 BAA82320 AF143096 AAD27893 AK127605 BAG54532 AU098526 AV709926 BC005234 AAH05234 BC070288 AAH70288 BC093700 AAH93700 BC104653 AAI04654 BC111394 AAI11395 BC112281 AAI12282 BE504461 BU952002 HQ258728 ADR83479 NM_001170747 NP_001164218 NM_006223 NP_006214 NR_033187 |
Function | Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. {ECO:0000269|PubMed:19369196}. |
Subcellular Location | Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1. |
Tissue Specificity | Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed. {ECO:0000269|PubMed:10100858, ECO:0000269|PubMed:10364457, ECO:0000269|PubMed:16522211}. |
Pin4 CRISPR/Cas9 KO Plasmid (h) - sc-410940 from Santa Cruz Biotechnology
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Pin4 HDR Plasmid (h) - sc-410940-HDR from Santa Cruz Biotechnology
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Pin4 Double Nickase Plasmid (h) - sc-410940-NIC from Santa Cruz Biotechnology
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Pin4 Double Nickase Plasmid (h2) - sc-410940-NIC-2 from Santa Cruz Biotechnology
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Pin4 CRISPR Activation Plasmid (h) - sc-410940-ACT from Santa Cruz Biotechnology
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Pin4 CRISPR Activation Plasmid (h2) - sc-410940-ACT-2 from Santa Cruz Biotechnology
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Pin4 Lentiviral Activation Particles (h) - sc-410940-LAC from Santa Cruz Biotechnology
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Pin4 Lentiviral Activation Particles (h2) - sc-410940-LAC-2 from Santa Cruz Biotechnology
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Pin4 siRNA (h) - sc-90997 from Santa Cruz Biotechnology
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Pin4 shRNA Plasmid (h) - sc-90997-SH from Santa Cruz Biotechnology
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Pin4 shRNA (h) Lentiviral Particles - sc-90997-V from Santa Cruz Biotechnology
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PIN4 RNAi - H00005303-R01 from Novus Biologicals
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PIN4 RNAi - H00005303-R02 from Novus Biologicals
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MISSION® esiRNA - EHU131971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16819 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16819 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04265 from Sigma-Aldrich
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PIN4 siRNA (Human) - CRH3545 from Cohesion Biosciences
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shRNA set against Human PIN4 (NM_006223.3) - SHH375936 from Creative biogene
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Human PIN4 siRNA - orb264047 from Biorbyt
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PIN4 shRNA Plasmid (Human) - CHH3545 from Cohesion Biosciences
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PIN4 miRNA 3'UTR clone - MiUTR3H-02674 from Creative biogene
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