BEST1

Gene Symbol BEST1
Entrez Gene 7439
Alt Symbol ARB, BEST, BMD, RP50, TU15B, VMD2
Species Human
Gene Type protein-coding
Description bestrophin 1
Other Description Best disease|Best1V1Delta2|bestrophin-1|vitelliform macular dystrophy protein 2
Swissprots Q8IZ80 Q8IUR9 O75904 A8K0W6 B7Z736 B7Z3J8 Q53YQ9 O76090
Accessions AAC64926 EAW73982 EAW73983 EAW73984 EAW73985 EAW73986 EAW73987 EAW73988 O76090 AB209451 BAD92688 AF057169 AAC64343 AF057170 AAC64344 AF073501 AAC33766 AK289681 BAF82370 AK293701 BAH11574 AK294577 BAH11817 AK295450 BAH12072 AK295580 BAH12111 AK295838 BAH12198 AK295998 BAH12234 AK298747 BAH12865 AK301392 BAH13472 AK309076 AY515704 AAR99654 BC015220 AAH15220 BC041664 AAH41664 CA388926 JQ954696 AFR11385 XM_005274210 XP_005274267 XM_005274215 XP_005274272 XM_005274216 XP_005274273 XM_005274218 XP_005274275 XM_005274219 XP_005274276 XM_005274221 XP_005274278 XM_011545229 XP_011543531 XM_011545230 XP_011543532 XM_011545231 XP_011543533 XM_011545232 XP_011543534 XM_011545233 XP_011543535 NM_001139443 NP_001132915 NM_001300786 NP_001287715 NM_001300787 NP_001287716 NM_004183 NP_004174
Function Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. {ECO:0000269|PubMed:11904445, ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19853238}; Multi-pass membrane protein {ECO:0000269|PubMed:19853238}. Basolateral cell membrane {ECO:0000269|PubMed:19853238}.
Tissue Specificity Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

Bestrophin (C-14) - sc-22027 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Bestrophin (C-14): sc-22027. Western blot analysis of Bestrophin expression in Y79 (A) and SK-N-SH (B) whole cell lysates.

Bestrophin (E6-6) - sc-32792 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bestrophin (E6-6): sc-32792. Western blot analysis of Bestrophin expression in porcine retinal epithelium tissue extract.

Bestrophin (H-93) - sc-292163 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Bestrophin antibody - ab14927 from Abcam

Prices $388.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab14927 staining HEK-293 cells transfected with human Bestrophin 1 by ICC/IF.  Cells were PFA fixed and permeabilized in 0.5% Triton X-100 prior to blocking in 5% goat serum for 20 minutes at 25°C.  The primary antibody was diluted 1/100 and incubated with the sample for 12 hours at 4°C.  An Alexa Fluor® 488 conjugated goat anti-rabbit antibody was used as the secondary.  Bestrophin transfected in HEK-293 cells is labeled with green fluorescence. Nuclei were counterstained with DAPI (blue).See Abreview

Anti-Bestrophin antibody - ab14929 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of ab14929 staining in human normal hippocampus formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab14929, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Bestrophin antibody - ab14928 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of hESC-RPE monolayers, staining Bestrophin with ab14928. Cells were fixed with 4% paraformaldehyde, permeabilized with 0.1% Triton X-100 and blocked with 3% BSA for 1 hour. Cells were incubated with primary antibody (1/500) for 1 hour at room temperature. An AlexaFluor&reg568-conjugated goat anti-rabbit IgG (1/800) was used as the secondary antibody.

Anti-Bestrophin antibody - ab155252 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bestrophin antibody (ab155252) at 1/1000 dilutionLane 1 : NT2D1 whole cell lysateLane 2 : PC3 whole cell lysateLane 3 : U-87 MG whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Bestrophin antibody - ab172044 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Bestrophin antibody (ab172044) at 1 µg/mlLane 1 : Bestrophin transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-Bestrophin antibody [E6-6] - ab2182 from Abcam

Prices $401.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone E6-6
ab2182 staining pig retinal pigment epithelium tissue sections.  The tissue was fixed with paraformaldehyde, permeabilised in 0.5% TX100, 5% goat serum, 1XPBS, and blocked with 5% serum for 20 minutes at 25°C.  The primary anitbody was diluted 1/500 in 1% goat serum, 0.1% TX100, 1XPBS and incubated for 12 hours at 4°C.   An Alexa Fluor® 488 conjugated goat anti-mouse was used as the secondary antibody.The image shows bestrophin, which localises to the retinal pigment epithelial (RPE) cells, labeled with green fluorescence. Nuclei were counterstained with DAPI (blue).See Abreview

Anti-BEST1 / BEST / Bestrophin Antibody (clone 1C2) - LS-C198431 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C2

Anti-BEST1 / BEST / Bestrophin Antibody - LS-C306538 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-BEST1 / BEST / Bestrophin Antibody - LS-C341835 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BEST1 / BEST / Bestrophin Antibody - LS-C2769 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Bestrophin Antibody (E6-6) - Western blot detection of Bestrophin (68 kDa) from human RPE cell lysate.

Anti-BEST1 / BEST / Bestrophin Antibody - LS-C335598 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using BEST1 antibody.

Bestrophin 1 Antibody (E6-6) - NB300-164 from Novus Biologicals

Prices $129.00, $349.00
Sizes 25 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone E6-6
Western Blot: Bestrophin 1 Antibody (E6-6) [NB300-164] - Detection of Bestrophin (68 kDa) from human RPE cell lysate.

Bestrophin 1 Antibody (1C2) - H00007439-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C2

Bestrophin 1 Antibody - H00007439-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: Bestrophin 1 Antibody [H00007439-B01P] - Analysis of BEST1 expression in transfected 293T cell line by BEST1 polyclonal antibody.  Lane 1: VMD2 transfected lysate(66.44 KDa). Lane 2: Non-transfected lysate.

Anti-BEST1 antibody produced in rabbit - SAB2700876 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-BEST1: <B>Cat. No. SAB2700876</B>: Western Blot analysis of BEST1 in extracts from <B>Lanes</B><BR/>A. NT2D1 <BR/>B. PC-3 using <B>Cat. No. SAB2700876</B> at a 1:1000 dilution.

Monoclonal Anti-VMD2 antibody produced in mouse - WH0007439M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C2
<B>Immunoblotting</B><BR/>Monoclonal Anti-VMD2, <B>Cat. No. WH0007439M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.11 kDa using immunogen protein lysate.

Anti-BEST1 antibody produced in rabbit - SAB2701026 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-BEST1: <B>Cat. No. SAB2701026</B>: Immunohistochemical analysis of paraffin-embedded U87 xenograft, using Bestrophin 1 antibody at 1:500 dilution.

Anti-BEST1 antibody produced in mouse - SAB1401400 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-BEST1, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1401400</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~66.44 kDa using BEST1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Bestrophin 1 antibody - GTX105387 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-Bestrophin 1 antibody used in Western blot. GTX105387

Bestrophin 1 antibody - GTX108854 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-Bestrophin 1 antibody used in IHC (Formalin-fixed paraffin-embedded sections). GTX108854

Bestrophin antibody - GTX14927 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

Bestrophin antibody - GTX14928 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
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