Gene Symbol | SF3A1 |
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Entrez Gene | 10291 |
Alt Symbol | PRP21, PRPF21, SAP114, SF3A120 |
Species | Human |
Gene Type | protein-coding |
Description | splicing factor 3a, subunit 1, 120kDa |
Other Description | SAP 114|pre-mRNA processing 21|pre-mRNA splicing factor SF3a (120 kDa subunit)|spliceosome-associated protein 114|splicing factor 3 subunit 1|splicing factor 3A subunit 1|splicing factor 3a, subunit 1, 120kD |
Swissprots | E9PAW1 Q15459 |
Accessions | AAC23435 EAW59878 EAW59879 Q15459 AI681052 AK098463 AK303273 BAG64353 AU100212 AV750569 BC001976 AAH01976 BC007684 AAH07684 BF965438 BI827130 BQ212479 BQ223575 BQ437843 BQ447452 CA440158 CK300534 CR456575 CAG30461 CU013174 CAK54605 CU013462 CAK54904 DB445415 DQ892687 ABM83613 DQ895931 ABM86857 X85237 CAA59494 NM_005877 NP_005868 NM_001005409 |
Function | Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. |
Top Pathways | Spliceosome |
Human SF3A1 full length protein - ab160931 from Abcam
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Human SF3A1 protein fragment - ab160932 from Abcam
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SF3A1 / SF3A120 Antibody Blocking Peptide - LS-E14855 from LifeSpan Bioscience
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SF3A1 / SF3A120 Antibody Blocking Peptide - LS-E14854 from LifeSpan Bioscience
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Recombinant Human SF3A1 Protein - H00010291-P01 from Novus Biologicals
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Recombinant Human SF3A1 Protein - H00010291-Q01 from Novus Biologicals
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SF3A1 Blocking Peptide - 33R-7702 from Fitzgerald
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SF3A1 Blocking Peptide - 33R-8124 from Fitzgerald
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SF3A1 / SAP114 - H00010291-P01 from Acris Antibodies
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SF3A1 / SAP114 - H00010291-Q01-10 from Acris Antibodies
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SF3A1 / SAP114 - H00010291-Q01-25 from Acris Antibodies
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SF3A1 fusion protein - ag8494 from Proteintech Group
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SF3A1 fusion protein - ag8196 from Proteintech Group
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Recombinant Human Splicing factor 3A subunit 1(SF3A1) - CSB-YP613594HU CSB-EP613594HU CSB-BP613594HU CSB-MP613594HU from Cusabio
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SF3A1 / SAP114 (transcript variant 1) - TP301098 from Acris Antibodies
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SF3A1 Recombinant Protein Antigen - NBP1-87215PEP from Novus Biologicals
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SF3A1 Recombinant Protein Antigen - NBP1-87214PEP from Novus Biologicals
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SF3A1-Antibody-Center-Blocking-Peptide - BP1932a from Abgent, a WuXi AppTec company
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SF3A1-Antibody-N-term-Blocking-Peptide - BP1932b from Abgent, a WuXi AppTec company
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SF3A1 Peptide, Human - M34GP14095H from Creative Peptides
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Splicing factor 3A subunit 1 (SF3A1), Recombinant Protein - MBS1445032 from MyBioSource
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