Gene Symbol | SF3A1 |
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Entrez Gene | 10291 |
Alt Symbol | PRP21, PRPF21, SAP114, SF3A120 |
Species | Human |
Gene Type | protein-coding |
Description | splicing factor 3a, subunit 1, 120kDa |
Other Description | SAP 114|pre-mRNA processing 21|pre-mRNA splicing factor SF3a (120 kDa subunit)|spliceosome-associated protein 114|splicing factor 3 subunit 1|splicing factor 3A subunit 1|splicing factor 3a, subunit 1, 120kD |
Swissprots | E9PAW1 Q15459 |
Accessions | AAC23435 EAW59878 EAW59879 Q15459 AI681052 AK098463 AK303273 BAG64353 AU100212 AV750569 BC001976 AAH01976 BC007684 AAH07684 BF965438 BI827130 BQ212479 BQ223575 BQ437843 BQ447452 CA440158 CK300534 CR456575 CAG30461 CU013174 CAK54605 CU013462 CAK54904 DB445415 DQ892687 ABM83613 DQ895931 ABM86857 X85237 CAA59494 NM_005877 NP_005868 NM_001005409 |
Function | Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. |
Subcellular Location | Nucleus {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. |
Top Pathways | Spliceosome |
SAP 114 CRISPR/Cas9 KO Plasmid (h) - sc-406985 from Santa Cruz Biotechnology
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SAP 114 HDR Plasmid (h) - sc-406985-HDR from Santa Cruz Biotechnology
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SAP 114 Double Nickase Plasmid (h) - sc-406985-NIC from Santa Cruz Biotechnology
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SAP 114 Double Nickase Plasmid (h2) - sc-406985-NIC-2 from Santa Cruz Biotechnology
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SAP 114 CRISPR Activation Plasmid (h) - sc-406985-ACT from Santa Cruz Biotechnology
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SAP 114 CRISPR Activation Plasmid (h2) - sc-406985-ACT-2 from Santa Cruz Biotechnology
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SAP 114 Lentiviral Activation Particles (h) - sc-406985-LAC from Santa Cruz Biotechnology
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SAP 114 Lentiviral Activation Particles (h2) - sc-406985-LAC-2 from Santa Cruz Biotechnology
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SAP 114 siRNA (h) - sc-62974 from Santa Cruz Biotechnology
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SAP 114 shRNA Plasmid (h) - sc-62974-SH from Santa Cruz Biotechnology
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SAP 114 shRNA (h) Lentiviral Particles - sc-62974-V from Santa Cruz Biotechnology
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SF3A1 RNAi - H00010291-R01 from Novus Biologicals
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SF3A1 RNAi - H00010291-R02 from Novus Biologicals
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MISSION® esiRNA - EHU119111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19182 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19182 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR13284 from Sigma-Aldrich
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SF3A1 siRNA (Human) - CRH6972 from Cohesion Biosciences
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SF3A1 - MBS8202991 from MyBioSource
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shRNA set against Human SF3A1 (NM_005877.4) - SHH405772 from Creative biogene
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shRNA set against Human SF3A1(NM_005877.4) - SHR218946 from Creative biogene
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shRNA set against Human SF3A1(NM_001005409.1) - SHR218982 from Creative biogene
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Human SF3A1 siRNA - orb267474 from Biorbyt
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SF3A1 shRNA Plasmid (Human) - CHH6972 from Cohesion Biosciences
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SF3A1 miRNA 3'UTR clone - MiUTR1H-09319 from Creative biogene
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