APIP

Gene Symbol APIP
Entrez Gene 51074
Alt Symbol APIP2, CGI-29, CGI29, MMRP19, hAPIP
Species Human
Gene Type protein-coding
Description APAF1 interacting protein
Other Description APAF1-interacting protein|MTRu-1-P dehydratase|methylthioribulose-1-phosphate dehydratase|probable methylthioribulose-1-phosphate dehydratase
Swissprots A8K9D3 Q96HK2 Q6PJX6 Q8WVU2 Q9Y318 Q96GX9
Accessions EAW68161 Q96GX9 AF088034 AF132963 AAD27738 AK225249 AK226157 AK292648 BAF85337 AK302225 BAG63579 BC008440 AAH08440 BC009077 AAH09077 BC017594 AAH17594 BP200131 DA729016 HQ448158 ADQ32639 XM_011520154 XP_011518456 XM_011520155 XP_011518457 NM_015957 NP_057041
Function Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Tissue Specificity Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. {ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Top Pathways Cysteine and methionine metabolism

APIP (D-8) - sc-390721 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
APIP (D-8): sc-390721. Western blot analysis of APIP expression in non-transfected 293: sc-110760 (A), human APIP transfected 293: sc-111191 (B) and HeLa (C) whole cell lysates.

APIP (C-9) - sc-376666 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
APIP (C-9): sc-376666. Western blot analysis of APIP expression in non-transfected: sc-110760 (A) and human APIP transfected: sc-111191 (B) 293 whole cell lysates.

APIP (G-2) - sc-393194 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
APIP (G-2): sc-393194. Western blot analysis of APIP expression in non-transfected: sc-110760 (A) and human APIP transfected: sc-111191 (B) 293 whole cell lysates.

APIP (D-20) - sc-66318 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
APIP (D-20): sc-66318. Western blot analysis of APIP expression in non-transfected: sc-110760 (A) and human APIP transfected: sc-111191 (B) 293 whole cell lysates.

APIP (G-14) - sc-66319 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
APIP (G-14): sc-66319. Western blot analysis of APIP expression in non-transfected: sc-110760 (A) and human APIP transfected: sc-111191 (B) 293 whole cell lysates.

APIP (H-72) - sc-292256 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
APIP (H-72): sc-292256. Western blot analysis of APIP expression in non-transfected: sc-110760 (A) and human APIP transfected: sc-111191 (B) 293 whole cell lysates.

APIP (19F461) - sc-56000 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-APIP antibody - ab128585 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-APIP antibody (ab128585) at 1/1000 dilution + Human fetal kidney lysate

Anti-APIP antibody [19F461] - ab22060 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 19F461
Western blot analysis of APIP2 in A) recombinant protein, B) HeLa, and C) 293 whole cell lysate using ab22060 at 2 ug/ml.

Anti-APIP Antibody (aa2-156) - LS-C179024 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-APIP Antibody IHC-plus™ - LS-B2016 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-APIP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2016 concentration 10 ug/ml.

Anti-APIP Antibody IHC-plus™ - LS-B8924 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-APIP antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-APIP Antibody - LS-C69133 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-APIP Antibody - LS-C69134 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-APIP Antibody (aa13-30) - LS-C147948 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-APIP Antibody (aa127-140) - LS-C147949 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-APIP Antibody (clone 19F424) - LS-C500 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 19F424
Western blot of APIP in recombinant protein using antibody at 2 ug/ml.

Anti-APIP Antibody (clone 19F461) - LS-C499 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 19F461
Western blot of APIP2 in A) recombinant protein, B) HeLa, and C) 293 whole cell lysate using antibody at 2 ug/ml.

Anti-APIP Antibody (aa143-192) - LS-C107767 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
APIP antibody LS-C107767 Western blot of 721_B cell lysate.

Anti-APIP Antibody (N-Terminus) - LS-C201681 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human MCF7. APIP antibody dilution 1.0 ug/ml.

APIP Antibody (19F461) - NB100-56567 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 19F461
Western Blot: APIP Antibody (19F461) [NB100-56567] - Analysis of APIP2 in (A) recombinant protein and (B) HeLa cell lysate using APIP antibody at 2 ug/ml.

APIP Antibody - NB100-56383 from Novus Biologicals

Prices $99.00, $229.00
Sizes 25 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: APIP Antibody [NB100-56383] - analysis of APIP 2 in human muscle using APIP 2 antibody at 2 ug/ml.

APIP Antibody (19F424) - NB100-56568 from Novus Biologicals

Prices $99.00, $299.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 19F424
Western Blot: APIP Antibody (19F424) [NB100-56568] - Western blot analysis of APIP in recombinant protein using NB100-56568 at 2 ug/ml.

APIP Antibody - NBP1-89040 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: APIP Antibody [NBP1-89040] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

APIP Antibody - NBP1-89039 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more