| Gene Symbol |
APIP
|
| Entrez Gene |
51074
|
| Alt Symbol |
APIP2, CGI-29, CGI29, MMRP19, hAPIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
APAF1 interacting protein
|
| Other Description |
APAF1-interacting protein|MTRu-1-P dehydratase|methylthioribulose-1-phosphate dehydratase|probable methylthioribulose-1-phosphate dehydratase
|
| Swissprots |
A8K9D3 Q96HK2 Q6PJX6 Q8WVU2 Q9Y318 Q96GX9
|
| Accessions |
EAW68161 Q96GX9 AF088034 AF132963 AAD27738 AK225249 AK226157 AK292648 BAF85337 AK302225 BAG63579 BC008440 AAH08440 BC009077 AAH09077 BC017594 AAH17594 BP200131 DA729016 HQ448158 ADQ32639 XM_011520154 XP_011518456 XM_011520155 XP_011518457 NM_015957 NP_057041
|
| Function |
Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
|
| Tissue Specificity |
Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. {ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
|
| Top Pathways |
Cysteine and methionine metabolism
|