APIP

Gene Symbol APIP
Entrez Gene 51074
Alt Symbol APIP2, CGI-29, CGI29, MMRP19, hAPIP
Species Human
Gene Type protein-coding
Description APAF1 interacting protein
Other Description APAF1-interacting protein|MTRu-1-P dehydratase|methylthioribulose-1-phosphate dehydratase|probable methylthioribulose-1-phosphate dehydratase
Swissprots A8K9D3 Q96HK2 Q6PJX6 Q8WVU2 Q9Y318 Q96GX9
Accessions EAW68161 Q96GX9 AF088034 AF132963 AAD27738 AK225249 AK226157 AK292648 BAF85337 AK302225 BAG63579 BC008440 AAH08440 BC009077 AAH09077 BC017594 AAH17594 BP200131 DA729016 HQ448158 ADQ32639 XM_011520154 XP_011518456 XM_011520155 XP_011518457 NM_015957 NP_057041
Function Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211}.
Subcellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Tissue Specificity Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. {ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Top Pathways Cysteine and methionine metabolism

APIP CRISPR/Cas9 KO Plasmid (h) - sc-406018 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APIP HDR Plasmid (h) - sc-406018-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APIP Double Nickase Plasmid (h) - sc-406018-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APIP Double Nickase Plasmid (h2) - sc-406018-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APIP CRISPR Activation Plasmid (h) - sc-406018-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APIP CRISPR Activation Plasmid (h2) - sc-406018-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APIP Lentiviral Activation Particles (h) - sc-406018-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APIP Lentiviral Activation Particles (h2) - sc-406018-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APIP siRNA (h) - sc-61976 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APIP shRNA Plasmid (h) - sc-61976-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APIP shRNA (h) Lentiviral Particles - sc-61976-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU105091 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3319 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3319 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03130 from Sigma-Aldrich

Category miRNA

APIP siRNA (Human) - CRH9497 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

APIP - MBS8222019 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human APIP (NM_015957.2) - SHH238238 from Creative biogene

Category siRNA
Species Reactivities Human

Human APIP siRNA - orb269999 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

APIP shRNA Plasmid (Human) - CHH9497 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

APIP miRNA 3'UTR clone - MiUTR1H-00465 from Creative biogene

Species Reactivities Human
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