APIP

Gene Symbol	APIP
Entrez Gene	51074
Alt Symbol	APIP2, CGI-29, CGI29, MMRP19, hAPIP
Species	Human
Gene Type	protein-coding
Description	APAF1 interacting protein
Other Description	APAF1-interacting protein|MTRu-1-P dehydratase|methylthioribulose-1-phosphate dehydratase|probable methylthioribulose-1-phosphate dehydratase
Swissprots	A8K9D3 Q96HK2 Q6PJX6 Q8WVU2 Q9Y318 Q96GX9
Accessions	EAW68161 Q96GX9 AF088034 AF132963 AAD27738 AK225249 AK226157 AK292648 BAF85337 AK302225 BAG63579 BC008440 AAH08440 BC009077 AAH09077 BC017594 AAH17594 BP200131 DA729016 HQ448158 ADQ32639 XM_011520154 XP_011518456 XM_011520155 XP_011518457 NM_015957 NP_057041
Function	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211}.
Subcellular Location	Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Tissue Specificity	Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney. {ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
Top Pathways	Cysteine and methionine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APIP full length protein - ab128440 from Abcam Category Protein Prices $297.00 Sizes 100 µg Source E. coli Species Human

Human APIP protein fragment - ab127159 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

APIP Antibody Blocking Peptide - LS-E20673 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APIP Recombinant Protein - H00051074-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human APIP Protein - NBP1-98917 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E.coli Species Human

APIP Protein - GTX111264-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

Human APIP protein - orb167900 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

APIP Blocking Peptide - 33R-3330 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

APIP protein (His tag) - 80R-2353 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

APIP (1-242, His-tag) - AR50438PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

APIP (1-242, His-tag) - AR50438PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

APIP - H00051074-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

APIP - H00051074-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

APIP, 1-242aa, Human, His tag, E.coli - 01-P1614 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

APIP fusion protein - Ag2729 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

APIP Human - PRPS-1193 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human APIP Protein - BP002121-PRO-1186 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. Coli-derived. Species Human

APIP, 1-242aa, Recombinant Protein - GWB-P0424H from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human APAF1 Interacting Protein, His-tagged - APIP-6855H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human APIP, GST-tagged - APIP-9740H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Methylthioribulose-1-phosphate dehydratase(mtnB) - CSB-YP882279XBL CSB-EP882279XBL CSB-BP882279XBL CSB-MP882279XBL from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Xylella

Recombinant Human Probable methylthioribulose-1-phosphate dehydratase(APIP) - CSB-YP839332HU CSB-EP839332HU CSB-BP839332HU CSB-MP839332HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Methylthioribulose-1-phosphate dehydratase(mtnB) - CSB-YP767500BQE CSB-EP767500BQE CSB-BP767500BQE CSB-MP767500BQE from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Bacillus

Recombinant Methylthioribulose-1-phosphate dehydratase(mtnB) - CSB-YP724080YAH CSB-EP724080YAH CSB-BP724080YAH CSB-MP724080YAH from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Yersinia

Recombinant Probable methylthioribulose-1-phosphate dehydratase(LmjF28.1840, LmjF_28_1840) - CSB-YP703009LOG CSB-EP703009LOG CSB-BP703009LOG CSB-MP703009LOG from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Leishmania

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