Casp1
| Gene Symbol | Casp1 |
|---|---|
| Entrez Gene | 12362 |
| Alt Symbol | ICE, Il1bc |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | caspase 1 |
| Other Description | CASP-1|IL-1 beta-converting enzyme|IL-1B converting enzyme|IL-1BC|caspase-1|interleukin 1 beta-converting enzyme|interleukin-1 beta convertase|interleukin-1 beta-converting enzyme|p45 |
| Swissprots | P29452 |
| Accessions | AAA56992 EDL09320 EDL09321 EDL09322 EDL09323 P29452 AK132826 AK163069 BC008152 AAH08152 L03799 AAA39306 L28095 AAA20209 NM_009807 NP_033937 |
| Function | Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | High level expression seen in spleen and lung, low level expression seen in brain, heart, liver, kidney, testis and skeletal muscle. |
| Top Pathways | Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A |
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