| Gene Symbol |
Casp1
|
| Entrez Gene |
12362
|
| Alt Symbol |
ICE, Il1bc
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
caspase 1
|
| Other Description |
CASP-1|IL-1 beta-converting enzyme|IL-1B converting enzyme|IL-1BC|caspase-1|interleukin 1 beta-converting enzyme|interleukin-1 beta convertase|interleukin-1 beta-converting enzyme|p45
|
| Swissprots |
P29452
|
| Accessions |
AAA56992 EDL09320 EDL09321 EDL09322 EDL09323 P29452 AK132826 AK163069 BC008152 AAH08152 L03799 AAA39306 L28095 AAA20209 NM_009807 NP_033937
|
| Function |
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
High level expression seen in spleen and lung, low level expression seen in brain, heart, liver, kidney, testis and skeletal muscle.
|
| Top Pathways |
Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A
|