Gene Symbol | Casp1 |
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Entrez Gene | 12362 |
Alt Symbol | ICE, Il1bc |
Species | Mouse |
Gene Type | protein-coding |
Description | caspase 1 |
Other Description | CASP-1|IL-1 beta-converting enzyme|IL-1B converting enzyme|IL-1BC|caspase-1|interleukin 1 beta-converting enzyme|interleukin-1 beta convertase|interleukin-1 beta-converting enzyme|p45 |
Swissprots | P29452 |
Accessions | AAA56992 EDL09320 EDL09321 EDL09322 EDL09323 P29452 AK132826 AK163069 BC008152 AAH08152 L03799 AAA39306 L28095 AAA20209 NM_009807 NP_033937 |
Function | Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | High level expression seen in spleen and lung, low level expression seen in brain, heart, liver, kidney, testis and skeletal muscle. |
Top Pathways | Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A |
Active mouse Caspase-1 full length protein - ab52079 from Abcam
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Caspase-1 Protein - NBP1-99224 from Novus Biologicals
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Recombinant Mouse Caspase-1 Protein - NBP1-99607 from Novus Biologicals
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Caspase 1 (active) recombinant protein - GTX65327 from GeneTex
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Caspase 1 (Active) recombinant protein - GTX65328 from GeneTex
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Caspase 1 protein - 30R-2413 from Fitzgerald
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Mouse Caspase 1 Protein - abx065750 from Abbexa
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Caspase-1 - P4484 from Acris Antibodies
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Caspase 1 (CASP1), Mouse - 20-7843 from ARP American Research Products
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Recombinant Caspase 1 (CASP1) - RPB592Mu01 from Cloud-clone
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Recombinant Caspase 1 (CASP1) - RPB592Mu02 from Cloud-clone
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Recombinant Mouse Caspase-1(Casp1) ,partial - CSB-YP004543MO CSB-EP004543MO CSB-BP004543MO CSB-MP004543MO from Cusabio
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Caspase-1, mouse recombinant - 1181-100 from Biovision
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Caspase-1, mouse recombinant - 1181-25 from Biovision
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Caspase 1 (CASP1) - RPU140659 from Biomatik
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Caspase 1 (CASP1), Recombinant Protein - MBS2011263 from MyBioSource
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Caspase-1, Recombinant Protein - MBS845387 from MyBioSource
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Caspase-1 (Casp1), partial, Recombinant Protein - MBS958847 from MyBioSource
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Recombinant Mouse CASP1 Protein - CASP1-2748M from Creative Biomart
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Recombinant Caspase 1 (CASP1) - RPU40659 from Biomatik
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CASP1 Recombinant Protein (OPCD01869) - OPCD01869 from Aviva Systems Biology
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Caspase-1, Mouse recombinant - 268-10025-1 from RayBiotech
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