PDK4

Gene Symbol	PDK4
Entrez Gene	5166
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 4
Other Description	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial|[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 4|pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
Swissprots	Q16654
Accessions	AAB67048 AAC50670 EAL24128 EAW76757 EAW76758 EAW76759 Q16654 AF334710 AK096428 BAG53287 AK098151 BAG53583 AK223328 BAD97048 AK312424 BAG35334 BC040239 AAH40239 DA923767 DB035430 DQ891256 ABM82182 DQ894441 ABM85367 U54617 AAC50669 NM_002612 NP_002603
Function	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid
Subcellular Location	Mitochondrion matrix.
Tissue Specificity	Ubiquitous; highest levels of expression in heart and skeletal muscle. {ECO:0000269|PubMed:14966024, ECO:0000269|PubMed:21816445}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PDK4-cDNA-Clone - DC07338 from Abgent, a WuXi AppTec company Prices $556.20 Sizes 10 µg Species Human Accession NM_002612

PDK4 - MBS1266793 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC040239

Human PDK4 Gene cDNA Clone (full-length ORF Clone) - HG10743-M from Sino Biological Species Human Accession NM_002612.3

Human PDHK4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10743-CM from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10743-NY from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10743-ANG from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, C-His tag - HG10743-CH from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid - HG10743-M-N from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10743-M-F from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10743-ACR from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10743-ANR from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10743-ACG from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid - HG10743-UT from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10743-NF from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, N-His tag - HG10743-NH from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10743-NM from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10743-CF from Sino Biological Species Human

Human PDHK4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10743-CY from Sino Biological Species Human

Human PDK4 ORF clone(NM_002612.3) - CDCL185682 from Creative biogene Species Human

Human PDK4 ORF Clone (BC040239) - CDCS410863 from Creative biogene Species Human Accession A4D1H4

Human PDHK4 Gene ORF cDNA clone in cloning vector - HG10743-G from Sino Biological Species Human

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