PDK4

Gene Symbol PDK4
Entrez Gene 5166
Alt Symbol -
Species Human
Gene Type protein-coding
Description pyruvate dehydrogenase kinase, isozyme 4
Other Description [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial|[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 4|pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
Swissprots Q16654
Accessions AAB67048 AAC50670 EAL24128 EAW76757 EAW76758 EAW76759 Q16654 AF334710 AK096428 BAG53287 AK098151 BAG53583 AK223328 BAD97048 AK312424 BAG35334 BC040239 AAH40239 DA923767 DB035430 DQ891256 ABM82182 DQ894441 ABM85367 U54617 AAC50669 NM_002612 NP_002603
Function Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid
Subcellular Location Mitochondrion matrix.
Tissue Specificity Ubiquitous; highest levels of expression in heart and skeletal muscle. {ECO:0000269|PubMed:14966024, ECO:0000269|PubMed:21816445}.

Pyruvate Dehydrogenase Kinase isoform 4 Human ELISA Kit - ab126582 from Abcam

Category ELISA Kit
Prices $438.00
Sizes 1 x 96 tests
Sensitivity > 3.9 ng/ml
Range 3.9 ng/ml - 250 ng/ml
Example standard curve of serially diluted purified human PDK4 in the linear working range of the assay.

Pyruvate Dehydrogenase Kinase Isozyme 4, PDK4, Human, ELISA Kit - E-EL-H1092 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.938
Range 1.563-100ng/mL

Pyruvate Dehydrogenase Kinase Isozyme 4, PDK4, Mouse, ELISA Kit - E-EL-M0997 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Pyruvate Dehydrogenase Kinase Isozyme 4, PDK4, Rat, ELISA Kit - E-EL-R0835 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Pyruvate Dehydrogenase Kinase Isozyme 4, PDK4, Rabbit, ELISA Kit - E-EL-RB1891 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Pyruvate Dehydrogenase Kinase Isozyme 4, PDK4, Chicken, ELISA Kit - E-EL-Ch1326 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Pyruvate Dehydrogenase Kinase Isozyme 4, PDK4, Porcine, ELISA Kit - E-EL-P0893 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.938
Range 1.563-100ng/mL

Pyruvate Dehydrogenase Kinase Isozyme 4, PDK4, Guinea Pig, ELISA Kit - E-EL-GP1250 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Pyruvate Dehydrogenase Kinase Isozyme 4, PDK4, Monkey, ELISA Kit - E-EL-MK0127 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Human PDK4 ELISA Kit - HP0087 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine PDK4 ELISA Kit - AP0087 from NeoScientific

Category ELISA Kit
Prices $300.00, $480.00
Sizes 100 µl, 200 µl

Human PDK4(Pyruvate Dehydrogenase Kinase Isozyme 4) ELISA Kit - E-EL-H1092 from Elabscience

Category ELISA Kit
Sensitivity 0.94 ng/mL
Range 1.56—100 ng/mL

PDK4, ELISA Kit - MBS2500633 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of Mouse PDK4 is 0.188ng/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero).
Range 0.313-20ng/mL

PDK4, ELISA Kit - MBS2503963 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563--100ng/mL

PDK4, ELISA Kit - MBS2512160 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563--100ng/mL

PDK4, ELISA Kit - MBS2511158 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

PDK4, ELISA Kit - MBS2510681 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

PDK4, ELISA Kit - MBS2501224 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 46.875pg/mL
Range 78.125-5000pg/mL

PDK4, ELISA Kit - MBS2505906 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/mL
Range 0.156--10ng/mL

PDK4, ELISA Kit - MBS2500538 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.375ng/mL
Range 0.625-40ng/mL

Pyruvate Dehydrogenase Kinase Isozyme 4, ELISA Kit - MBS018971 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 4, ELISA Kit - MBS017958 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 4, ELISA Kit - MBS023592 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate Dehydrogenase Kinase Isozyme 4 - MBS047160 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00
Sizes 48 strip wells, 96 strip wells

Pyruvate Dehydrogenase Kinase Isozyme 4, ELISA Kit - MBS727890 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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