PDK4

Gene Symbol	PDK4
Entrez Gene	5166
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 4
Other Description	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial|[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial|pyruvate dehydrogenase kinase, isoenzyme 4|pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
Swissprots	Q16654
Accessions	AAB67048 AAC50670 EAL24128 EAW76757 EAW76758 EAW76759 Q16654 AF334710 AK096428 BAG53287 AK098151 BAG53583 AK223328 BAD97048 AK312424 BAG35334 BC040239 AAH40239 DA923767 DB035430 DQ891256 ABM82182 DQ894441 ABM85367 U54617 AAC50669 NM_002612 NP_002603
Function	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid
Subcellular Location	Mitochondrion matrix.
Tissue Specificity	Ubiquitous; highest levels of expression in heart and skeletal muscle. {ECO:0000269|PubMed:14966024, ECO:0000269|PubMed:21816445}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDK4 full length protein - ab125560 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Recombinant PDK4 (human), active - ab110356 from Abcam Prices $365.00 Sizes 50 µg Source E. coli Species Human

Human PDK4 full length protein - ab112337 from Abcam Category Protein Source Wheat germ Species Human

Human PDK4 peptide - ab98254 from Abcam Category Peptide

PDK4 Antibody Blocking Peptide - LS-E3634 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK4 Antibody Blocking Peptide - LS-E11539 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK4 Antibody Blocking Peptide - LS-E8632 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK4 Antibody Blocking Peptide - LS-E8633 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK4 Antibody Blocking Peptide - LS-E8634 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK4 Blocking Peptide - NBP1-07049PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

PDK4 Blocking Peptide - NBP1-07047PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human PDK4 Protein - H00005166-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PDK4 Partial Recombinant Protein - H00005166-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDK4 Peptide - P2132 from Novus Biologicals Category Peptide Species Human

PDK4-Antibody-Center-D98-Blocking-Peptide - BP7041f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDK4-Antibody-E265-Blocking-Peptide - BP7041c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDK4-Antibody-C-term-Blocking-Peptide - BP7041b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDK4 Blocking Peptide - 33R-6121 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human PDK4 Protein - abx068808 from Abbexa Category Protein Source E.coli Species Human

PDK4 - H00005166-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDK4 - H00005166-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDK4 - H00005166-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDK4 - H00005166-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDK4 - P5618 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Pyruvate Dehydrogenase Kinase Isozyme 4 (PDK4), Human - 20-7337 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

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