| Gene Symbol |
GPR37
|
| Entrez Gene |
2861
|
| Alt Symbol |
EDNRBL, PAELR, hET(B)R-LP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 37 (endothelin receptor type B-like)
|
| Other Description |
ETBR-LP-1|G-protein coupled receptor 37|Parkin-associated endothelin receptor-like receptor|endothelin B receptor-like protein 1|probable G-protein coupled receptor 37|prosaposin receptor GPR37
|
| Swissprots |
A4D0Y6 Q8TD39 O14768 O15354 O00348
|
| Accessions |
AAD08853 CAA73080 EAL24325 EAW83613 O15354 AF017262 AAB70008 AF502281 AAM18625 BC040007 AAH40007 DB475687 DB495592 DB517451 JF432421 ADZ15638 NM_005302 NP_005293
|
| Function |
Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. {ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:9526070}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}.
|
| Tissue Specificity |
Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). {ECO:0000269|PubMed:9526070}.
|