Gene Symbol | GPR37 |
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Entrez Gene | 2861 |
Alt Symbol | EDNRBL, PAELR, hET(B)R-LP |
Species | Human |
Gene Type | protein-coding |
Description | G protein-coupled receptor 37 (endothelin receptor type B-like) |
Other Description | ETBR-LP-1|G-protein coupled receptor 37|Parkin-associated endothelin receptor-like receptor|endothelin B receptor-like protein 1|probable G-protein coupled receptor 37|prosaposin receptor GPR37 |
Swissprots | A4D0Y6 Q8TD39 O14768 O15354 O00348 |
Accessions | AAD08853 CAA73080 EAL24325 EAW83613 O15354 AF017262 AAB70008 AF502281 AAM18625 BC040007 AAH40007 DB475687 DB495592 DB517451 JF432421 ADZ15638 NM_005302 NP_005293 |
Function | Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. {ECO:0000269|PubMed:11439185, ECO:0000269|PubMed:23690594, ECO:0000269|PubMed:9526070}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17059562}; Multi-pass membrane protein {ECO:0000269|PubMed:17059562}. |
Tissue Specificity | Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). {ECO:0000269|PubMed:9526070}. |
Human GPCR GPR37 full length protein - ab158569 from Abcam
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PAEL Receptor / GPR37 Antibody Blocking Peptide - LS-E23510 from LifeSpan Bioscience
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PAEL Receptor / GPR37 Antibody Blocking Peptide - LS-E28977 from LifeSpan Bioscience
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PAEL Receptor / GPR37 Antibody Blocking Peptide - LS-E8231 from LifeSpan Bioscience
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PAEL Receptor / GPR37 Antibody Blocking Peptide - LS-E8232 from LifeSpan Bioscience
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PAEL Receptor / GPR37 Antibody Blocking Peptide - LS-E28208 from LifeSpan Bioscience
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PAEL Receptor / GPR37 Antibody Blocking Peptide - LS-E28217 from LifeSpan Bioscience
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PAEL Receptor / GPR37 Antibody Blocking Peptide - LS-E28228 from LifeSpan Bioscience
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Recombinant Human GPR37 Protein - H00002861-P02 from Novus Biologicals
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Recombinant Human GPR37 Protein - H00002861-G01 from Novus Biologicals
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GPR37 Peptide - P2057 from Novus Biologicals
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GPR37 Peptide - P2056 from Novus Biologicals
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Pael-R-GPR37-Antibody-C-term-Blocking-Peptide - BP6410b from Abgent, a WuXi AppTec company
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Pael-R-GPR37-Antibody-N-term-Blocking-Peptide - BP6410a from Abgent, a WuXi AppTec company
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GPR37 / PAEL Receptor - H00002861-G01 from Acris Antibodies
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GPR37 / PAEL Receptor - H00002861-P02 from Acris Antibodies
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GPR37 fusion protein - ag6591 from Proteintech Group
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Recombinant G Protein Coupled Receptor 37 (GPR37) - RPG720Hu01 from Uscn Life Science Inc.
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Human GPR37 Protein (His Tag) - 13496-H08H-20 from Sino Biological
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Recombinant G Protein Coupled Receptor 37 (GPR37) - RPG720Hu01 from Cloud-clone
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Probable G-protein coupled receptor 37 (GPR37), Recombinant Protein - MBS1008361 from MyBioSource
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Recombinant Human GPR37 Protein (His tag) - PKSH030621 from Elabscience
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Recombinant Human GPR37 Protein, His-tagged - GPR37-542H from Creative Biomart
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GPR37 Recombinant Protein Antigen - NBP2-49540PEP from Novus Biologicals
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GPR37 Peptide, Human - M34GP06572H from Creative Peptides
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