CDCP1
| Gene Symbol | CDCP1 |
|---|---|
| Entrez Gene | 64866 |
| Alt Symbol | CD318, SIMA135, TRASK |
| Species | Human |
| Gene Type | protein-coding |
| Description | CUB domain containing protein 1 |
| Other Description | CUB domain-containing protein 1|membrane glycoprotein gp140|subtractive immunization M plus HEp3-associated 135 kDa protein|transmembrane and associated with src kinases |
| Swissprots | Q9H8C2 Q49UB4 Q96QU7 Q6U9Y2 Q9H5V8 Q8WU91 Q9H676 Q6NT71 |
| Accessions | EAW64737 EAW64738 Q9H5V8 AF468010 AAO33397 AK023834 BAB14695 AK026187 BAB15388 AK026329 AK026622 BAB15511 AK314441 AY026461 AAK02058 AY167484 AAO34538 AY358779 AAQ89139 AY375452 AAR21289 BC021099 AAH21099 BC069254 AAH69254 BC148605 AAI48606 BC153169 AAI53170 CD367582 XM_011534024 XP_011532326 NM_022842 NP_073753 NM_178181 NP_835488 |
| Function | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}. |
| Subcellular Location | Isoform 1: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Shedding may also lead to a soluble peptide. |
| Tissue Specificity | Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12660814, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225}. |
Human CDCP1 full length protein - ab131825 from Abcam
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Human CDCP1 peptide - ab22864 from Abcam
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CDCP1 Antibody Blocking Peptide - LS-E4124 from LifeSpan Bioscience
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CDCP1 Antibody Blocking Peptide - LS-E25279 from LifeSpan Bioscience
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CDCP1 Antibody Blocking Peptide - LS-E29412 from LifeSpan Bioscience
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CDCP1 Antibody Blocking Peptide - LS-E29413 from LifeSpan Bioscience
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CDCP1 Antibody Blocking Peptide - LS-E29414 from LifeSpan Bioscience
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CDCP1 Antibody Blocking Peptide - LS-E29415 from LifeSpan Bioscience
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Recombinant Human CDCP1 Protein - H00064866-P01 from Novus Biologicals
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CDCP1 Recombinant Protein - H00064866-G01 from Novus Biologicals
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CDCP1-Antibody-C-term-Blocking-Peptide - BP16364b from Abgent, a WuXi AppTec company
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CDCP1 (isoform 1: C term) blocking peptide - GTX82973-PEP from GeneTex
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Human CDCP1 (His Tag) protein - orb232301 from Biorbyt
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CD318 (phospho-Tyr707) Blocking Peptide - abx063958 from Abbexa
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CD318 Blocking Peptide - abx063959 from Abbexa
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CDCP1 Peptide - AC21-0107-P from Abcore
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CD318 / CDCP1 - H00064866-G01 from Acris Antibodies
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CD318 / CDCP1 - H00064866-P01-10 from Acris Antibodies
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CD318 / CDCP1 - H00064866-P01-25 from Acris Antibodies
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CDCP1 Peptide - 45-031P from ProSci
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CDCP1 fusion protein - ag3439 from Proteintech Group
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Recombinant Human CDCP1, Fc tagged - CDCP1-8567H from Creative Biomart
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Recombinant CUB Domain Containing Protein 1 (CDCP1) - RPB779Hu01 from Uscn Life Science Inc.
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Human CDCP1 / CD318 Protein (Fc Tag) - 13262-H05H-20 from Sino Biological
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Human CDCP1 / CD318 Protein (His Tag) - 13262-H08H-20 from Sino Biological
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