CDCP1

Gene Symbol CDCP1
Entrez Gene 64866
Alt Symbol CD318, SIMA135, TRASK
Species Human
Gene Type protein-coding
Description CUB domain containing protein 1
Other Description CUB domain-containing protein 1|membrane glycoprotein gp140|subtractive immunization M plus HEp3-associated 135 kDa protein|transmembrane and associated with src kinases
Swissprots Q9H8C2 Q49UB4 Q96QU7 Q6U9Y2 Q9H5V8 Q8WU91 Q9H676 Q6NT71
Accessions EAW64737 EAW64738 Q9H5V8 AF468010 AAO33397 AK023834 BAB14695 AK026187 BAB15388 AK026329 AK026622 BAB15511 AK314441 AY026461 AAK02058 AY167484 AAO34538 AY358779 AAQ89139 AY375452 AAR21289 BC021099 AAH21099 BC069254 AAH69254 BC148605 AAI48606 BC153169 AAI53170 CD367582 XM_011534024 XP_011532326 NM_022842 NP_073753 NM_178181 NP_835488
Function May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}.
Subcellular Location Isoform 1: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Shedding may also lead to a soluble peptide.
Tissue Specificity Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12660814, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225}.

Phospho-CDCP1 (Tyr806) Antibody - 13024 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from ZR-75-1 cells, untreated (-) or treated with a Cub1 antibody (+), using Phospho-CDCP1 (Tyr806) Antibody (upper) and CDCP1 Antibody #4115 (lower).

Phospho-CDCP1 (Tyr734) Antibody - 9050 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HCT 116 cells, untreated (-) or treated with Cub1 mAb (+), using Phospho-CDCP1 (Tyr734) Antibody (upper) or CDCP1 Antibody #4115 (lower).

Phospho-CDCP1 (Tyr743) Antibody - 13093 from Cell Signaling Technology

Prices $279.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from ZR-75-1 cells, untreated (-) or treated with a Cub1 antibody (+), using Phospho-CDCP1 (Tyr743) Antibody (upper) and CDCP1 Antibody #4115 (lower).

Phospho-CDCP1 (Tyr707) Antibody - 13111 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of ZR-75-1 cells, untreated (-) or treated with a Cub1 antibody (+), using Phospho-CDCP1 (Tyr707) Antibody (upper) and CDCP1 Antibody #4115 (lower).

CDCP1 (D8M5K) Rabbit mAb - 12327 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D8M5K
Western blot analysis of extracts from various cell lines using CDCP1 (D8M5K) Rabbit mAb.

CDCP1 Antibody - 4115 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from PC3 and HT29 cells using CDCP1 Antibody.

CDCP1 (D1W9N) Rabbit mAb - 13794 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1W9N
Western blot analysis of extracts from COLO 201 and ZR-75-30 cells using CDCP1 (D1W9N) Rabbit mAb (upper) and GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower). As expected, MCF7 cells are negative for CDCP1.

CDCP1 Antibody - 4192 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal

CDCP1 (E-20) - sc-32844 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CDCP1 (E-20): sc-32844. Western blot analysis of CDCP1 expression in A549 whole cell lysate.

CDCP1 (H-300) - sc-292398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CDCP1 (K-19) - sc-32845 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CDCP1 (K-19): sc-32845. Western blot analysis of CDCP1 expression in mouse colon tissue extract.

CDCP1 (T-17) - sc-32846 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CDCP1 (T-17): sc-32846. Western blot analysis of CDCP1 expression in A-431 whole cell lysate.

Anti-CDCP1 antibody - ab1377 from Abcam

Prices $380.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CDCP1 antibody - ab65241 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab65241 at 1/500-1/1000 dilution staining CDCP1 in HepG2 cells by Immunofluorescence, in the absence (-) or presence (+) of the immunising peptide.

Anti-CDCP1 antibody - ab107165 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CDCP1 antibody (ab107165) at 1 µg/ml (Milk Blocked 3%)Lane 1 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lane 2 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330) with Immunizing peptide at 1 µg/mlLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CDCP1 antibody - ab172655 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-CDCP1 antibody (ab172655) at 1 µg/mlLane 1 : CDCP1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-CDCP1 antibody [4F1] - ab118268 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4F1
All lanes : Anti-CDCP1 antibody [4F1] (ab118268) at 1/500 dilutionLane 1 : Non transfected cell lysateLane 2 : CDCP1 transfected HEK293T cell lysateLysates/proteins at 5 µg per lane.

Anti-CDCP1 antibody - C-terminal - ab172934 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CDCP1 antibody - C-terminal (ab172934) at 1/100 dilution + NCI-H460 cell lysate at 35 µg

Anti-CDCP1 Antibody (clone 2C1) IHC-plus™ - LS-B11734 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C1
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CDCP1 Antibody (clone 2B8) - LS-C337193 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B8
IHC of paraffin-embedded Human lymphoma tissue using anti-CDCP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).

Anti-CDCP1 Antibody (aa25-667) - LS-C78973 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-CDCP1 Antibody (aa25-667) - LS-C125337 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-CDCP1 Antibody (Internal) - LS-C155122 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDCP1 Antibody (C-Terminus) - LS-C34632 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
CDCP1 antibody (1 ug/ml) staining of Human Colon lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CDCP1 Antibody (aa691-740) - LS-C119266 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HepG2 cells, using CDCP1 Antibody. The picture on the right is treated with the synthesized peptide.
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