| Gene Symbol | CDCP1 |
|---|---|
| Entrez Gene | 64866 |
| Alt Symbol | CD318, SIMA135, TRASK |
| Species | Human |
| Gene Type | protein-coding |
| Description | CUB domain containing protein 1 |
| Other Description | CUB domain-containing protein 1|membrane glycoprotein gp140|subtractive immunization M plus HEp3-associated 135 kDa protein|transmembrane and associated with src kinases |
| Swissprots | Q9H8C2 Q49UB4 Q96QU7 Q6U9Y2 Q9H5V8 Q8WU91 Q9H676 Q6NT71 |
| Accessions | EAW64737 EAW64738 Q9H5V8 AF468010 AAO33397 AK023834 BAB14695 AK026187 BAB15388 AK026329 AK026622 BAB15511 AK314441 AY026461 AAK02058 AY167484 AAO34538 AY358779 AAQ89139 AY375452 AAR21289 BC021099 AAH21099 BC069254 AAH69254 BC148605 AAI48606 BC153169 AAI53170 CD367582 XM_011534024 XP_011532326 NM_022842 NP_073753 NM_178181 NP_835488 |
| Function | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12799299, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225, ECO:0000269|PubMed:16404722, ECO:0000269|PubMed:8647901}. |
| Subcellular Location | Isoform 1: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Shedding may also lead to a soluble peptide. |
| Tissue Specificity | Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. {ECO:0000269|PubMed:11466621, ECO:0000269|PubMed:12660814, ECO:0000269|PubMed:15153610, ECO:0000269|PubMed:16007225}. |
CDCP1 CRISPR/Cas9 KO Plasmid (h) - sc-404730 from Santa Cruz Biotechnology
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CDCP1 HDR Plasmid (h) - sc-404730-HDR from Santa Cruz Biotechnology
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CDCP1 Double Nickase Plasmid (h) - sc-404730-NIC from Santa Cruz Biotechnology
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CDCP1 Double Nickase Plasmid (h2) - sc-404730-NIC-2 from Santa Cruz Biotechnology
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CDCP1 CRISPR Activation Plasmid (h) - sc-404730-ACT from Santa Cruz Biotechnology
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CDCP1 CRISPR Activation Plasmid (h2) - sc-404730-ACT-2 from Santa Cruz Biotechnology
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CDCP1 Lentiviral Activation Particles (h) - sc-404730-LAC from Santa Cruz Biotechnology
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CDCP1 Lentiviral Activation Particles (h2) - sc-404730-LAC-2 from Santa Cruz Biotechnology
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CDCP1 siRNA (h) - sc-44640 from Santa Cruz Biotechnology
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CDCP1 shRNA Plasmid (h) - sc-44640-SH from Santa Cruz Biotechnology
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CDCP1 shRNA (h) Lentiviral Particles - sc-44640-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU049221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1131 from Sigma-Aldrich
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CDCP1 siRNA (Human) - CRJ2130 from Cohesion Biosciences
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CDCP1 - MBS8226838 from MyBioSource
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shRNA set against Human CDCP1 (NM_178181.1) - SHH260085 from Creative biogene
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shRNA set against Human CDCP1(NM_178181.1) - SHG162583 from Creative biogene
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shRNA set against Human CDCP1(NM_022842.3) - SHG162619 from Creative biogene
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CDCP1 shRNA Plasmid (Human) - CHJ2130 from Cohesion Biosciences
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CDCP1 miRNA 3'UTR clone - MiUTR1H-01968 from Creative biogene
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CDCP1 miRNA 3'UTR clone - MiUTR1H-01969 from Creative biogene
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