Gene Symbol | SNCB |
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Entrez Gene | 6620 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | synuclein, beta |
Other Description | beta-synuclein |
Swissprots | Q6IAX7 Q16143 |
Accessions | AAC80286 EAW85063 EAW85064 Q16143 AB209029 BAD92266 AK309135 BC002902 AAH02902 BM543516 BM967045 BT006627 AAP35273 CR457027 CAG33308 DQ892970 ABM83896 DQ896218 ABM87217 JF960950 AEQ54756 JF960951 AEQ54757 JF960952 AEQ54758 JF960953 AEQ54759 S69965 AAB30860 XM_006714914 XP_006714977 XM_006714915 XP_006714978 XM_006714916 XP_006714979 XM_011534640 XP_011532942 NM_001001502 NP_001001502 NM_003085 NP_003076 |
Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Expressed predominantly in brain; concentrated in presynaptic nerve terminals. |
SNCB 293T Cell Transient Overexpression Lysate(Denatured) - H00006620-T01 from Acris Antibodies
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SNCB overexpression lysate - LY401075 from Acris Antibodies
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SNCB overexpression lysate - LY424365 from Acris Antibodies
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SNCB 293 Cell Lysate - 401003 from ABBIOTEC
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SNCB 293 Cell Lysate - 410068 from ABBIOTEC
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beta-Synuclein Overexpression Lysate (Native) - NBL1-16276 from Novus Biologicals
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beta-Synuclein Overexpression Lysate (Native) - NBL1-16275 from Novus Biologicals
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β-synuclein (h): 293T Lysate - sc-159288 from Santa Cruz Biotechnology
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β-synuclein (h2): 293T Lysate - sc-159500 from Santa Cruz Biotechnology
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SNCB Over-expression Lysate Product - GWB-B2852D from Genway Biotech
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SNCB Over-expression Lysate Product - GWB-8A93D9 from Genway Biotech
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beta-Synuclein Overexpression Lysate (Denatured) - H00006620-T01 from Novus Biologicals
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Panoply™ Human SNCB Knockdown Stable Cell Line - CSC-DC014805 from Creative biogene
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