SNCB

Gene Symbol SNCB
Entrez Gene 6620
Alt Symbol -
Species Human
Gene Type protein-coding
Description synuclein, beta
Other Description beta-synuclein
Swissprots Q6IAX7 Q16143
Accessions AAC80286 EAW85063 EAW85064 Q16143 AB209029 BAD92266 AK309135 BC002902 AAH02902 BM543516 BM967045 BT006627 AAP35273 CR457027 CAG33308 DQ892970 ABM83896 DQ896218 ABM87217 JF960950 AEQ54756 JF960951 AEQ54757 JF960952 AEQ54758 JF960953 AEQ54759 S69965 AAB30860 XM_006714914 XP_006714977 XM_006714915 XP_006714978 XM_006714916 XP_006714979 XM_011534640 XP_011532942 NM_001001502 NP_001001502 NM_003085 NP_003076
Function Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed predominantly in brain; concentrated in presynaptic nerve terminals.

α/β-synuclein (N-19) - sc-7012 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
α/β-synuclein (N-19): sc-7012. Western blot analysis of β-synuclein expression in non-transfected: sc-117752 (A) and human β-synuclein transfected: sc-159500 (B) 293T whole cell lysates.

α/β/γ-synuclein (FL-140) - sc-10717 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
α/β/γ-synuclein (FL-140): sc-10717. Western blot analysis of α/β/γ-synuclein expression in mouse brain tissue extract.

β-synuclein (C-20) - sc-9565 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-synuclein (C-20): sc-9565. Western blot analysis of β-synuclein in rat brain (A) and mouse brain (B) extracts.

β-synuclein (K-20) - sc-9564 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
β-synuclein (K-20): sc-9564. Western blot analysis of β-synuclein expression in non-transfected: sc-117752 (A) and human β-synuclein transfected: sc-159288 (B) 293T whole cell lysates and mouse brain tissue extract (C).

Anti-alpha + beta Synuclein antibody - ab21975 from Abcam

Prices $376.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal
Staining of Lewy body in Dementia with Lewy body disease tissue. Primary antibody ab21975 at 1/1000, secondary antibody biotinylated Donkey and sheep followed by Vector ABC and DAB substrate.

Anti-alpha + beta Synuclein antibody [EP1646Y] - ab51252 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1646Y
Overlay histogram showing SH-SY5Y cells stained with ab51252 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab51252, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-alpha + beta Synuclein antibody [EP1646Y] (Alexa Fluor® 488) - ab199086 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1646Y
ab199086 staining alpha+beta Synuclein in PC12 cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab199086 at 1/50 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-alpha + beta Synuclein antibody [EP1646Y] (Alexa Fluor® 647) - ab199304 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1646Y
ab199304 staining alpha+beta synuclein in PC12 cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab199304 at 1/200 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 2µg/ml (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-alpha + beta Synuclein antibody [Syn 202] - ab24715 from Abcam

Prices $394.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone Syn 202
ab24715 staining alpha + beta Synuclein in rat glioblastoma cell line C6 by Immunocytochemistry/ Immunofluorescence.Cells were fixed in paraformaldehyde, permeabilized using 0,1% Triton X 100 in PBS, blocked with 0.5% BSA for 30 minutes and then incubated with ab24715 at a 1/50 dilution for 16 hours at 4°C. The secondary used was a Cy3 conjugated goat anti-mouse polyclonal used at a 1/400 dilution. Nuclei are counterstained with DAPI.See Abreview

Anti-beta Synuclein antibody - ab6165 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab6165 staining beta synuclein in human occipital cortex.Left panel: with primary antibody diluted 1:4000. Right panel: isotype control.Sections were stained using an automated system (DAKO Autostainer Plus), at room temperature: sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffers citrate pH6.1. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-beta Synuclein antibody - ab167607 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-beta Synuclein antibody (ab167607) at 1 µg/mlLane 1 : beta Synuclein transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-Mouse IgG

Anti-beta Synuclein antibody - ab53167 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-beta Synuclein antibody (ab53167) at 1/500 dilutionLane 1 : HeLa cell extractLane 2 : HeLa cell extract with immunising peptide

Anti-beta Synuclein antibody - ab6163 from Abcam

Prices $370.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-beta Synuclein antibody - ab6164 from Abcam

Prices $370.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

Anti-beta Synuclein antibody - ab17394 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-beta Synuclein antibody - ab15532 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ab15532 staining beta Synuclein in human brain by Immunohistochemistry (FFPE-sections).

Anti-beta Synuclein antibody - ab16420 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-beta Synuclein antibody [EP1537Y] - ab76111 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1537Y
ab76111 at 1/100-1/250 dilution staining beta Synuclein in PC12 cells by Immunofluorescence.

Anti-beta Synuclein antibody, prediluted - ab15533 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15533 staining beta Synuclein in human brain by Immunohistochemistry (FFPE-sections).

Anti-beta Synuclein antibody - C-terminal - ab189276 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-beta Synuclein antibody - C-terminal (ab189276) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysate with synthesized peptide

Anti-pan Synuclein antibody - ab53726 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-pan Synuclein antibody (ab53726) at 1/500 dilutionLane 1 : rat heart lysateLane 2 : rat heart lysate with immunizing peptideLysates/proteins at 5 µg per lane.SecondaryAlkaline Phosphatase Goat Anti-Rabbit IgG (H+L)

Anti-pan Synuclein antibody - ab15534 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Human brain stained with ab15534

Anti-pan Synuclein antibody - ab59270 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab59270 at a dilution of 1/50. Left hand image - without immunising peptide; right hand image - with immunising peptide.

Anti-pan Synuclein antibody, prediluted - ab15535 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15535 staining pan Synuclein in Human brain tissue.

Anti-SNCB / Beta-Synuclein Antibody (aa85-134) IHC-plus™ - LS-B7627 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SNCB / Beta-Synuclein antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7627 concentration 10 ug/ml.
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