| Gene Symbol |
MYBBP1A
|
| Entrez Gene |
10514
|
| Alt Symbol |
P160, PAP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MYB binding protein (P160) 1a
|
| Other Description |
myb-binding protein 1A|p53-activated protein-2
|
| Swissprots |
Q9BW49 Q9BQG0 Q9UF99 Q9P0V5 Q86VM3
|
| Accessions |
EAW90435 EAW90436 EAW90437 Q9BQG0 AF147709 AAF33021 AK095205 AK293458 BAG56953 AK301622 BAG63107 AK303150 BAG64253 AK307948 AL133098 CAB61409 AL136595 CAB66530 AY093673 AAM44451 BC000641 AAH00641 BC050546 AAH50546 BF111023 CB243989 DC346952 EU832503 ACE87675 XM_011523616 XP_011521918 NM_001105538 NP_001099008 NM_014520 NP_055335
|
| Function |
May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. {ECO:0000250|UniProtKB:Q7TPV4}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:12429849}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250|UniProtKB:Q7TPV4}.
|