Gene Symbol | MYBBP1A |
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Entrez Gene | 10514 |
Alt Symbol | P160, PAP2 |
Species | Human |
Gene Type | protein-coding |
Description | MYB binding protein (P160) 1a |
Other Description | myb-binding protein 1A|p53-activated protein-2 |
Swissprots | Q9BW49 Q9BQG0 Q9UF99 Q9P0V5 Q86VM3 |
Accessions | EAW90435 EAW90436 EAW90437 Q9BQG0 AF147709 AAF33021 AK095205 AK293458 BAG56953 AK301622 BAG63107 AK303150 BAG64253 AK307948 AL133098 CAB61409 AL136595 CAB66530 AY093673 AAM44451 BC000641 AAH00641 BC050546 AAH50546 BF111023 CB243989 DC346952 EU832503 ACE87675 XM_011523616 XP_011521918 NM_001105538 NP_001099008 NM_014520 NP_055335 |
Function | May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. {ECO:0000250|UniProtKB:Q7TPV4}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:12429849}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Note=Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar. {ECO:0000250|UniProtKB:Q7TPV4}. |
MYBBP1A CRISPR/Cas9 KO Plasmid (h) - sc-407644 from Santa Cruz Biotechnology
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MYBBP1A HDR Plasmid (h) - sc-407644-HDR from Santa Cruz Biotechnology
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MYBBP1A Double Nickase Plasmid (h) - sc-407644-NIC from Santa Cruz Biotechnology
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MYBBP1A Double Nickase Plasmid (h2) - sc-407644-NIC-2 from Santa Cruz Biotechnology
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MYBBP1A CRISPR Activation Plasmid (h) - sc-407644-ACT from Santa Cruz Biotechnology
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MYBBP1A CRISPR Activation Plasmid (h2) - sc-407644-ACT-2 from Santa Cruz Biotechnology
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MYBBP1A Lentiviral Activation Particles (h) - sc-407644-LAC from Santa Cruz Biotechnology
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MYBBP1A Lentiviral Activation Particles (h2) - sc-407644-LAC-2 from Santa Cruz Biotechnology
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MYBBP1A siRNA (h) - sc-93603 from Santa Cruz Biotechnology
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MYBBP1A shRNA Plasmid (h) - sc-93603-SH from Santa Cruz Biotechnology
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MYBBP1A shRNA (h) Lentiviral Particles - sc-93603-V from Santa Cruz Biotechnology
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MYBBP1A RNAi - H00010514-R01 from Novus Biologicals
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MISSION® esiRNA - EHU018921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14792 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14792 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05055 from Sigma-Aldrich
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MYBBP1A siRNA (Human) - CRH7142 from Cohesion Biosciences
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shRNA set against Human MYBBP1A (NM_014520.3) - SHH347428 from Creative biogene
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shRNA set against Human MYBBP1A(NM_014520.3) - SHH210161 from Creative biogene
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Human MYBBP1A siRNA - orb267644 from Biorbyt
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MYBBP1A shRNA Plasmid (Human) - CHH7142 from Cohesion Biosciences
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MYBBP1A miRNA 3'UTR clone - MiUTR1H-06551 from Creative biogene
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MYBBP1A miRNA 3'UTR clone - MiUTR3H-07168 from Creative biogene
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