MAP4K4

Gene Symbol MAP4K4
Entrez Gene 9448
Alt Symbol FLH21957, HEL-S-31, HGK, MEKKK4, NIK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase kinase 4
Other Description HPK/GCK-like kinase HGK|MAPK/ERK kinase kinase kinase 4|MEK kinase kinase 4|Ste20 group protein kinase HGK|epididymis secretory protein Li 31|hepatocyte progenitor kinase-like/germinal center kinase-like kinase|nck-interacting kinase
Swissprots O75172 Q9NST7 O95819
Accessions AAY14969 AAY14970 AAY24319 EAX01805 EAX01806 EAX01807 EAX01808 EAX01809 EAX01810 O95819 AB013385 BAA33714 AB014587 BAA31662 AF096300 AAD16137 AK000380 BAA91127 AK001272 AK025610 AK074592 AK074900 AK130085 AK295610 BAH12124 AK296396 BAH12341 AK307879 AL137755 CAB70907 AY212247 AAO32626 AY834276 AAV97884 BC010909 BC040077 BC045694 BC051791 BC054038 BC064691 BC065036 BC156089 AAI56090 BC156887 AAI56888 BU595561 BU625485 DB086475 DR002278 EU794634 ACJ13688 XM_005264044 XP_005264101 XM_005264045 XP_005264102 XM_005264046 XP_005264103 XM_005264047 XP_005264104 XM_005264048 XP_005264105 XM_005264049 XP_005264106 XM_005264050 XP_005264107 XM_005264052 XP_005264109 XM_005264053 XP_005264110 XM_005264054 XP_005264111 XM_005264055 XP_005264112 XM_005264056 XP_005264113 XM_005264057 XP_005264114 XM_005264058 XP_005264115 XM_005264059 XP_005264116 XM_005264060 XP_005264117 XM_005264062 XP_005264119 XM_005264063 XP_005264120 XM_005264064 XP_005264121 XM_005264065 XP_005264122 XM_005264066 XP_005264123 XM_005264068 XP_005264125 XM_005264069 XP_005264126 XM_005264071 XP_005264128 XM_006712865 XP_006712928 XM_006712866 XP_006712929 XM_006712867 XP_006712930 XM_006712868 XP_006712931 XM_006712869 XP_006712932 XM_011512201 XP_011510503 XM_011512202 XP_011510504 XM_011512203 XP_011510505 XM_011512204 XP_011510506 XM_011512205 XP_011510507 NM_001242559 NP_001229488 NM_001242560 NP_001229489 NM_004834 NP_004825 NM_145686 NP_663719 NM_145687 NP_663720
Function Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:9890973}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14966141}.
Tissue Specificity Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. {ECO:0000269|PubMed:9890973}.
Top Pathways MAPK signaling pathway

Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), Human, ELISA Kit - CSB-EL013439HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml

mitogen-activated protein kinase kinase kinase kinase 4, ELISA Kit - MBS917832 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml

Human Mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) ELISA kit - CSB-EL013439HU from Cusabio

Category ELISA Kit
Sensitivity 5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml

Human MAP4K4 ELISA Kit - E024758 from Biobool

Category ELISA Kit
Sensitivity 5.8 pg/ml

MAP4K4 ELISA Kit (Human) (OKCA00731) - OKCA00731 from Aviva Systems Biology

Category ELISA Kit
Prices $590.00
Sizes 96 wells
Sensitivity 5.8 pg/mL
Range 23.5 pg/mL-1,500 pg/mL

anti-MAP4K4 antibody [SP177] - ARG53262 from Arigo Biolaboratories

Category ELISA Kit

anti-MAP4K4 antibody [SP177] (Ready-to-Use) - ARG53263 from Arigo Biolaboratories

Category ELISA Kit

Human MAP4K4 ELISA Kit - orb404849 from Biorbyt

Category ELISA Kit
Sensitivity 5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml
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