MAP4K4

Gene Symbol MAP4K4
Entrez Gene 9448
Alt Symbol FLH21957, HEL-S-31, HGK, MEKKK4, NIK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase kinase 4
Other Description HPK/GCK-like kinase HGK|MAPK/ERK kinase kinase kinase 4|MEK kinase kinase 4|Ste20 group protein kinase HGK|epididymis secretory protein Li 31|hepatocyte progenitor kinase-like/germinal center kinase-like kinase|nck-interacting kinase
Swissprots O75172 Q9NST7 O95819
Accessions AAY14969 AAY14970 AAY24319 EAX01805 EAX01806 EAX01807 EAX01808 EAX01809 EAX01810 O95819 AB013385 BAA33714 AB014587 BAA31662 AF096300 AAD16137 AK000380 BAA91127 AK001272 AK025610 AK074592 AK074900 AK130085 AK295610 BAH12124 AK296396 BAH12341 AK307879 AL137755 CAB70907 AY212247 AAO32626 AY834276 AAV97884 BC010909 BC040077 BC045694 BC051791 BC054038 BC064691 BC065036 BC156089 AAI56090 BC156887 AAI56888 BU595561 BU625485 DB086475 DR002278 EU794634 ACJ13688 XM_005264044 XP_005264101 XM_005264045 XP_005264102 XM_005264046 XP_005264103 XM_005264047 XP_005264104 XM_005264048 XP_005264105 XM_005264049 XP_005264106 XM_005264050 XP_005264107 XM_005264052 XP_005264109 XM_005264053 XP_005264110 XM_005264054 XP_005264111 XM_005264055 XP_005264112 XM_005264056 XP_005264113 XM_005264057 XP_005264114 XM_005264058 XP_005264115 XM_005264059 XP_005264116 XM_005264060 XP_005264117 XM_005264062 XP_005264119 XM_005264063 XP_005264120 XM_005264064 XP_005264121 XM_005264065 XP_005264122 XM_005264066 XP_005264123 XM_005264068 XP_005264125 XM_005264069 XP_005264126 XM_005264071 XP_005264128 XM_006712865 XP_006712928 XM_006712866 XP_006712929 XM_006712867 XP_006712930 XM_006712868 XP_006712931 XM_006712869 XP_006712932 XM_011512201 XP_011510503 XM_011512202 XP_011510504 XM_011512203 XP_011510505 XM_011512204 XP_011510506 XM_011512205 XP_011510507 NM_001242559 NP_001229488 NM_001242560 NP_001229489 NM_004834 NP_004825 NM_145686 NP_663719 NM_145687 NP_663720
Function Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:9890973}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14966141}.
Tissue Specificity Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. {ECO:0000269|PubMed:9890973}.
Top Pathways MAPK signaling pathway

HGK CRISPR/Cas9 KO Plasmid (h) - sc-403395 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGK HDR Plasmid (h) - sc-403395-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGK Double Nickase Plasmid (h) - sc-403395-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGK Double Nickase Plasmid (h2) - sc-403395-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGK CRISPR Activation Plasmid (h) - sc-403395-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGK CRISPR Activation Plasmid (h2) - sc-403395-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGK Lentiviral Activation Particles (h) - sc-403395-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGK Lentiviral Activation Particles (h2) - sc-403395-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HGK siRNA (h) - sc-39243 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HGK shRNA Plasmid (h) - sc-39243-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HGK shRNA (h) Lentiviral Particles - sc-39243-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HGK/MAP4K4 RNAi - H00009448-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

HGK/MAP4K4 RNAi - H00009448-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® siRNA - SIHK1179 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1177 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1178 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN13001 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13001 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MAP4K4 siRNA (Human) - CRH6267 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

HGK/MAP4K4 RNAi - H00009448-R06 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MAP4K4 (NM_004834.4) - SHH337835 from Creative biogene

Category siRNA
Species Reactivities Human

Human MAP4K4 siRNA - orb266769 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MAP4K4 shRNA Plasmid (Human) - CHH6267 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAP4K4 miRNA 3'UTR clone - MiUTR4H-TG05344 from Creative biogene

Species Reactivities Human
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