MAP4K4

Gene Symbol	MAP4K4
Entrez Gene	9448
Alt Symbol	FLH21957, HEL-S-31, HGK, MEKKK4, NIK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase kinase 4
Other Description	HPK/GCK-like kinase HGK|MAPK/ERK kinase kinase kinase 4|MEK kinase kinase 4|Ste20 group protein kinase HGK|epididymis secretory protein Li 31|hepatocyte progenitor kinase-like/germinal center kinase-like kinase|nck-interacting kinase
Swissprots	O75172 Q9NST7 O95819
Accessions	AAY14969 AAY14970 AAY24319 EAX01805 EAX01806 EAX01807 EAX01808 EAX01809 EAX01810 O95819 AB013385 BAA33714 AB014587 BAA31662 AF096300 AAD16137 AK000380 BAA91127 AK001272 AK025610 AK074592 AK074900 AK130085 AK295610 BAH12124 AK296396 BAH12341 AK307879 AL137755 CAB70907 AY212247 AAO32626 AY834276 AAV97884 BC010909 BC040077 BC045694 BC051791 BC054038 BC064691 BC065036 BC156089 AAI56090 BC156887 AAI56888 BU595561 BU625485 DB086475 DR002278 EU794634 ACJ13688 XM_005264044 XP_005264101 XM_005264045 XP_005264102 XM_005264046 XP_005264103 XM_005264047 XP_005264104 XM_005264048 XP_005264105 XM_005264049 XP_005264106 XM_005264050 XP_005264107 XM_005264052 XP_005264109 XM_005264053 XP_005264110 XM_005264054 XP_005264111 XM_005264055 XP_005264112 XM_005264056 XP_005264113 XM_005264057 XP_005264114 XM_005264058 XP_005264115 XM_005264059 XP_005264116 XM_005264060 XP_005264117 XM_005264062 XP_005264119 XM_005264063 XP_005264120 XM_005264064 XP_005264121 XM_005264065 XP_005264122 XM_005264066 XP_005264123 XM_005264068 XP_005264125 XM_005264069 XP_005264126 XM_005264071 XP_005264128 XM_006712865 XP_006712928 XM_006712866 XP_006712929 XM_006712867 XP_006712930 XM_006712868 XP_006712931 XM_006712869 XP_006712932 XM_011512201 XP_011510503 XM_011512202 XP_011510504 XM_011512203 XP_011510505 XM_011512204 XP_011510506 XM_011512205 XP_011510507 NM_001242559 NP_001229488 NM_001242560 NP_001229489 NM_004834 NP_004825 NM_145686 NP_663719 NM_145687 NP_663720
Function	Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:9890973}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:14966141}.
Tissue Specificity	Appears to be ubiquitous. Expressed in all tissue types examined. Isoform 5 appears to be more abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. {ECO:0000269|PubMed:9890973}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MAP4K4 protein fragment - ab101775 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus Species Human

Human MAP4K4 protein fragment - ab152989 from Abcam Category Protein Source Wheat germ Species Human

MAP4K4 Antibody Blocking Peptide - LS-E3298 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP4K4 Antibody Blocking Peptide - LS-E7374 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP4K4 Antibody Blocking Peptide - LS-E7381 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP4K4 Antibody Blocking Peptide - LS-E17737 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP4K4 Antibody Blocking Peptide - LS-E9418 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HGK/MAP4K4 Protein - H00009448-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

HGK/MAP4K4 Peptide - P1579 from Novus Biologicals Category Peptide Species Human

HGK/MAP4K4 Peptide - P1563 from Novus Biologicals Category Peptide Species Human

HGK/MAP4K4 Peptide - P2975 from Novus Biologicals Category Peptide Species Human

Phospho-MAP4K4S801-Antibody-Blocking-peptide - BP3444a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-MAP4K4S629-Antibody-Blocking-peptide - BP3428a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

NIK-Antibody-C-term-Blocking-peptide - BP8004a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAP4K4 Blocking Peptide - 33R-7076 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAP4K4 - H00009448-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAP4K4 - H00009448-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAP4K4 - P5559 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Recombinant Human MAP4K4 - MAP4K4-27603TH from Creative Biomart Category Protein Source Baculovirus

Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4, GST-tagged - MAP4K4-1042H from Creative Biomart Category Protein Species Human

HGK (R430) Peptide - BS2249P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4 - CSB-YP013439HU CSB-EP013439HU CSB-BP013439HU CSB-MP013439HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NIK, Peptide - MBS843586 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

Recombinant Human MAP4K4/HGK His - CSI13427 from Cell Science Prices $615.00 Sizes 10 μg Species Human

HGK/MAP4K4 Recombinant Protein Antigen - NBP1-84663PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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