| Gene Symbol |
RNGTT
|
| Entrez Gene |
8732
|
| Alt Symbol |
CAP1A, HCE, HCE1, hCAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA guanylyltransferase and 5'-phosphatase
|
| Other Description |
HCAP1|mRNA-capping enzyme
|
| Swissprots |
O60351 Q5TCW8 O60942 Q8WUM8 E1P513 O43483 E1P514 O60257
|
| Accessions |
EAW48566 EAW48567 EAW48568 EAW48569 EAW48570 O60942 AB009022 BAA25894 AB009023 BAA25895 AB009024 BAA25896 AB012142 BAA25198 AB012143 BAA25199 AF025654 AAB91559 AI193199 AK295719 BAG58562 AK299777 BAG61660 AK312407 BAG35320 BC019954 AAH19954 BP256840 BP396964 BX537450 CAD97693 JF432295 ADZ15512 XM_011536219 XP_011534521 XR_942617 NM_001286426 NP_001273355 NM_001286428 NP_001273357 NM_003800 NP_003791
|
| Function |
Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. {ECO:0000269|PubMed:21636784, ECO:0000269|PubMed:9473487, ECO:0000269|PubMed:9512541}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
|
| Top Pathways |
mRNA surveillance pathway
|