RNGTT

Gene Symbol	RNGTT
Entrez Gene	8732
Alt Symbol	CAP1A, HCE, HCE1, hCAP
Species	Human
Gene Type	protein-coding
Description	RNA guanylyltransferase and 5'-phosphatase
Other Description	HCAP1|mRNA-capping enzyme
Swissprots	O60351 Q5TCW8 O60942 Q8WUM8 E1P513 O43483 E1P514 O60257
Accessions	EAW48566 EAW48567 EAW48568 EAW48569 EAW48570 O60942 AB009022 BAA25894 AB009023 BAA25895 AB009024 BAA25896 AB012142 BAA25198 AB012143 BAA25199 AF025654 AAB91559 AI193199 AK295719 BAG58562 AK299777 BAG61660 AK312407 BAG35320 BC019954 AAH19954 BP256840 BP396964 BX537450 CAD97693 JF432295 ADZ15512 XM_011536219 XP_011534521 XR_942617 NM_001286426 NP_001273355 NM_001286428 NP_001273357 NM_003800 NP_003791
Function	Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. {ECO:0000269|PubMed:21636784, ECO:0000269|PubMed:9473487, ECO:0000269|PubMed:9512541}.
Subcellular Location	Nucleus {ECO:0000250}.
Tissue Specificity	Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
Top Pathways	mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RNGTT CRISPR/Cas9 KO Plasmid (h) - sc-405280 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RNGTT HDR Plasmid (h) - sc-405280-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RNGTT Double Nickase Plasmid (h) - sc-405280-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RNGTT Double Nickase Plasmid (h2) - sc-405280-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RNGTT CRISPR Activation Plasmid (h) - sc-405280-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RNGTT CRISPR Activation Plasmid (h2) - sc-405280-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RNGTT Lentiviral Activation Particles (h) - sc-405280-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RNGTT Lentiviral Activation Particles (h2) - sc-405280-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RNGTT siRNA (h) - sc-95119 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RNGTT shRNA Plasmid (h) - sc-95119-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RNGTT shRNA (h) Lentiviral Particles - sc-95119-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU140521 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0843 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0842 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0841 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN18447 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18447 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11509 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11509

RNGTT siRNA (Human) - CRH5751 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RNGTT RNAi - H00008732-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RNGTT - MBS827371 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RNGTT (NM_003800.3) - SHH397468 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RNGTT(NM_003800.3) - SHR188530 from Creative biogene Category siRNA Species Reactivities Human

RNGTT shRNA Plasmid (Human) - CHH5751 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RNGTT miRNA 3'UTR clone - MiUTR1H-08912 from Creative biogene Species Reactivities Human

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