| Gene Symbol |
PDK1
|
| Entrez Gene |
5163
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pyruvate dehydrogenase kinase, isozyme 1
|
| Other Description |
PDH kinase 1|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial|mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1|pyruvate dehydrogenase kinase, isoenzyme 1
|
| Swissprots |
E9PD65 Q15118 Q308M4 D3DPD8 B2R6T1 B7Z937
|
| Accessions |
AAY14915 EAX11173 EAX11174 Q15118 AK056110 AK294194 BAH11693 AK302321 BAH13672 AK304388 BAH14173 AK312700 BAG35578 AU118504 BC039158 AAH39158 BQ023252 BX485353 DC322401 DQ234350 ABB29979 DQ891300 ABM82226 DQ893348 ABM84274 DQ894484 ABM85410 DQ896668 ABM87667 L42450 AAC42009 XM_006712594 XP_006712657 XM_006712595 XP_006712658 XM_011511343 XP_011509645 XM_011511344 XP_011509646 XM_011511345 XP_011509647 XM_011511346 XP_011509648 XM_011511347 XP_011509649 XR_427093 XR_427094 XR_427095 XR_922942 XR_922943 XR_922944 XR_922945 XR_922946 NM_001278549 NP_001265478 NM_002610 NP_002601 NR_103729 NR_103731
|
| Function |
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:22195962}.
|
| Tissue Specificity |
Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:7499431}.
|
| Top Pathways |
Central carbon metabolism in cancer
|
![Western Blot: PDK1 Overexpression Lysate (Adult Normal) [NBL1-14249] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PDK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9392_PDK1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14249-img0002.jpg)