PDK1

Gene Symbol	PDK1
Entrez Gene	5163
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 1
Other Description	PDH kinase 1|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial|mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1|pyruvate dehydrogenase kinase, isoenzyme 1
Swissprots	E9PD65 Q15118 Q308M4 D3DPD8 B2R6T1 B7Z937
Accessions	AAY14915 EAX11173 EAX11174 Q15118 AK056110 AK294194 BAH11693 AK302321 BAH13672 AK304388 BAH14173 AK312700 BAG35578 AU118504 BC039158 AAH39158 BQ023252 BX485353 DC322401 DQ234350 ABB29979 DQ891300 ABM82226 DQ893348 ABM84274 DQ894484 ABM85410 DQ896668 ABM87667 L42450 AAC42009 XM_006712594 XP_006712657 XM_006712595 XP_006712658 XM_011511343 XP_011509645 XM_011511344 XP_011509646 XM_011511345 XP_011509647 XM_011511346 XP_011509648 XM_011511347 XP_011509649 XR_427093 XR_427094 XR_427095 XR_922942 XR_922943 XR_922944 XR_922945 XR_922946 NM_001278549 NP_001265478 NM_002610 NP_002601 NR_103729 NR_103731
Function	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:22195962}.
Tissue Specificity	Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:7499431}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDHK1 (C47H1) Rabbit mAb - 3820 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C47H1

PDK (H-300) - sc-28783 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PDK1 (A-13) - sc-30692 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PDK1 (C-20) - sc-7140 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PDK1 (V-17) - sc-30691 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody - ab92959 from Abcam Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody - ab90444 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody - ab47987 from Abcam Prices $388.00 Sizes 200 µl Host Goat Clonality Polyclonal

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody - ab126043 from Abcam Prices $376.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody - ab86963 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [2H3AA11] - ab110335 from Abcam Prices $385.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2H3AA11

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [4A11] - ab110025 from Abcam Prices $388.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 4A11

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [EPR13009] - ab175190 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13009

Anti-Mitochondrial Pyruvate dehydrogenase kinase 1 antibody [EPR13015] - C-terminal - ab180171 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR13015

Anti-pan PDK antibody [3H5BE12] - ab115321 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3H5BE12

Anti-PDK1 Antibody (aa421-436) - LS-C26009 from LifeSpan Bioscience Prices $355.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PDK1 Antibody (C-Terminus) - LS-C93136 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDK1 Antibody (Internal) - LS-C93137 from LifeSpan Bioscience Prices $435.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDK1 Antibody (clone AT2D6) - LS-C103496 from LifeSpan Bioscience Prices $255.00, $315.00 Sizes 50 µl, 100 µl Host Mouse Clonality Monoclonal Clone AT2D6

Anti-PDK1 Antibody - LS-C112630 from LifeSpan Bioscience Prices $290.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDK1 Antibody - LS-C131340 from LifeSpan Bioscience Prices $445.00 Sizes 100 µl Host Rabbit Clonality Monoclonal

Anti-PDK1 Antibody (aa123-133) - LS-C55254 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-PDK1 Antibody (C-Terminus, Biotin) - LS-C141003 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDK1 Antibody (aa287-336) - LS-C101357 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PDK1 Antibody (C-Terminus, DY650) - LS-C141004 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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