PDK1

Gene Symbol PDK1
Entrez Gene 5163
Alt Symbol -
Species Human
Gene Type protein-coding
Description pyruvate dehydrogenase kinase, isozyme 1
Other Description PDH kinase 1|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial|mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1|pyruvate dehydrogenase kinase, isoenzyme 1
Swissprots E9PD65 Q15118 Q308M4 D3DPD8 B2R6T1 B7Z937
Accessions AAY14915 EAX11173 EAX11174 Q15118 AK056110 AK294194 BAH11693 AK302321 BAH13672 AK304388 BAH14173 AK312700 BAG35578 AU118504 BC039158 AAH39158 BQ023252 BX485353 DC322401 DQ234350 ABB29979 DQ891300 ABM82226 DQ893348 ABM84274 DQ894484 ABM85410 DQ896668 ABM87667 L42450 AAC42009 XM_006712594 XP_006712657 XM_006712595 XP_006712658 XM_011511343 XP_011509645 XM_011511344 XP_011509646 XM_011511345 XP_011509647 XM_011511346 XP_011509648 XM_011511347 XP_011509649 XR_427093 XR_427094 XR_427095 XR_922942 XR_922943 XR_922944 XR_922945 XR_922946 NM_001278549 NP_001265478 NM_002610 NP_002601 NR_103729 NR_103731
Function Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:22195962}.
Tissue Specificity Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:7499431}.
Top Pathways Central carbon metabolism in cancer

PDK1 CRISPR/Cas9 KO Plasmid (h) - sc-401084 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK1 HDR Plasmid (h) - sc-401084-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK1 Double Nickase Plasmid (h) - sc-401084-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK1 Double Nickase Plasmid (h2) - sc-401084-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK1 CRISPR Activation Plasmid (h) - sc-401084-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK1 CRISPR Activation Plasmid (h2) - sc-401084-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK1 Lentiviral Activation Particles (h) - sc-401084-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK1 Lentiviral Activation Particles (h2) - sc-401084-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PDK1 siRNA (h) - sc-36203 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDK1 shRNA Plasmid (h) - sc-36203-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PDK1 shRNA (h) Lentiviral Particles - sc-36203-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU079981 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK1555 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1554 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1553 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1046 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1046 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PDK1 siRNA (Human) - CRH3443 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PDK-1 RNAi - H00005163-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PDK1 (NM_002610.3) - SHH372864 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PDK1(NM_002610.3) - SHR102264 from Creative biogene

Category siRNA
Species Reactivities Human

Human PDK1 siRNA - orb263945 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PDK1 shRNA Plasmid (Human) - CHH3443 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PDK1 miRNA 3'UTR clone - MiUTR1H-07744 from Creative biogene

Species Reactivities Human
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