PDK1

Gene Symbol	PDK1
Entrez Gene	5163
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	pyruvate dehydrogenase kinase, isozyme 1
Other Description	PDH kinase 1|[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial|mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1|pyruvate dehydrogenase kinase, isoenzyme 1
Swissprots	E9PD65 Q15118 Q308M4 D3DPD8 B2R6T1 B7Z937
Accessions	AAY14915 EAX11173 EAX11174 Q15118 AK056110 AK294194 BAH11693 AK302321 BAH13672 AK304388 BAH14173 AK312700 BAG35578 AU118504 BC039158 AAH39158 BQ023252 BX485353 DC322401 DQ234350 ABB29979 DQ891300 ABM82226 DQ893348 ABM84274 DQ894484 ABM85410 DQ896668 ABM87667 L42450 AAC42009 XM_006712594 XP_006712657 XM_006712595 XP_006712658 XM_011511343 XP_011509645 XM_011511344 XP_011509646 XM_011511345 XP_011509647 XM_011511346 XP_011509648 XM_011511347 XP_011509649 XR_427093 XR_427094 XR_427095 XR_922942 XR_922943 XR_922944 XR_922945 XR_922946 NM_001278549 NP_001265478 NM_002610 NP_002601 NR_103729 NR_103731
Function	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:7499431}.
Subcellular Location	Mitochondrion matrix {ECO:0000269|PubMed:22195962}.
Tissue Specificity	Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas. {ECO:0000269|PubMed:7499431}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Mitochondrial Pyruvate dehydrogenase kinase 1 full length protein - ab125580 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Recombinant Mitochondrial Pyruvate dehydrogenase kinase 1(human), active - ab110359 from Abcam Prices $365.00 Sizes 50 µg Source E. coli Species Human

Human Mitochondrial Pyruvate dehydrogenase kinase 1 full length protein - ab86986 from Abcam Category Protein Source E. coli Species Human

Human Mitochondrial Pyruvate dehydrogenase kinase 1 peptide - ab105480 from Abcam Category Peptide

Human Mitochondrial Pyruvate dehydrogenase kinase 1 peptide - ab48037 from Abcam Category Peptide Species Human

PDK1-Antibody-N-term-Blocking-Peptide - BP7038a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDK1 Protein (OPPA01992) - OPPA01992 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

PDK1 peptide - orb217731 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

Human PDK1 Protein - abx068804 from Abbexa Category Protein Source E.coli Species Human

PDK1 Peptide - AC21-0805-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PDK1 (29-436, His-tag) - AR09115PU-L from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

PDK1 (29-436, His-tag) - AR09115PU-N from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

PDK1 - H00005163-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDK1 - H00005163-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDK1 - P3527 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

PDK1 - P4190 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PDK1 - P5771 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

Pyruvate Dehydrogenase Kinase Isozyme 1, Human Recombinant - 228-11218-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human PDK1 - 228-11218-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human PDK1 - 228-11218-3 from RayBiotech Category Protein Prices $1,950.00 Sizes 3 µg Source Escherichia Coli. Species Human

PDK1, 29-436aa, Human, His-tagged, Recombinant, E.coli - 01-2121 from ARP American Research Products Category Protein Prices $139.00, $299.00, $639.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1), Human - 20-8564 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Human

PDK1 Peptide - 46-155P from ProSci Category Peptide Species Human, Rat

PDK1 fusion protein - ag13121 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PDHK1 Human Recombinant Protein - GWB-9C7357 from Genway Biotech Category Protein Prices $456.00 Sizes 10 µg Species Human

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