MBTPS1

Gene Symbol	MBTPS1
Entrez Gene	8720
Alt Symbol	PCSK8, S1P, SKI-1
Species	Human
Gene Type	protein-coding
Description	membrane-bound transcription factor peptidase, site 1
Other Description	endopeptidase S1P|membrane-bound transcription factor site-1 protease|proprotein convertase subtilisin/kexin type 8|site-1 protease|subtilisin/kexin isozyme-1
Swissprots	Q14703 Q24JQ2 Q9UF67 A8K6V8
Accessions	CCQ43234 EAW95505 EAW95506 Q14703 AK054744 AK091212 BAG52308 AK291773 BAF84462 AK299067 BAG61133 AL133583 CAB63727 AL701753 BC026330 BC114555 AAI14556 BC114961 AAI14962 BM048055 BM680126 BP364386 BX472644 D42053 BAA07653 NM_003791 NP_003782 NM_201268
Function	Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg- Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. {ECO:0000269|PubMed:21719679}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Golgi apparatus membrane {ECO:0000269|PubMed:9990022}; Single-pass type I membrane protein {ECO:0000269|PubMed:9990022}. Note=May sort to other organelles, including lysosomal and/or endosomal compartments.
Tissue Specificity	Widely expressed.
Top Pathways	Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

membrane-bound transcription factor peptidase, site 1, ELISA Kit - MBS9332243 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human S1P (Sphingosine 1 phosphate) ELISA Kit - E-EL-H2583 from Iwai North America Inc. Category ELISA Kit Prices $649.00 Sizes 1 kit Sensitivity 1.875ng/mL Range 3.125--200ng/mL

Human MBTPS1 / S1P ELISA Kit (Sandwich ELISA) - LS-F21833 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 1.875 ng/ml Range 3.125 - 200 ng/ml

Human MBTPS1 ELISA Kit - E024145 from Biobool Category ELISA Kit

anti-MBTPS1 antibody - ARG56137 from Arigo Biolaboratories Category ELISA Kit

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9344008 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9344639 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9366709 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9348912 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9354001 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9365668 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9345687 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9344105 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9348995 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9362966 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9348962 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9350069 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9366885 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9359566 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9346493 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9345529 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9375819 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9363779 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9359649 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Membrane-Bound Transcription Factor Site-1 Protease (MBTPS1), ELISA Kit - MBS9363627 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more